ECM Proteins Nidogen-1 and Decorin Restore Functionality of Human Islets of Langerhans upon Hypoxic Conditions Jeyagaran A, Urbanczyk M, Carvajal-Berrio D, Baldissera T, Kaiser PD, Kuhlburger L, Czemmel S, Nahnsen S, Duffy GP, Brucker SY, Layland SL, Schenke-Layland K. Adv Healthc Mater. 2024 Nov 7:e2403017. https://doi.org/10.1002/adhm.202403017
Patient iPSC-derived neural progenitor cells display aberrant cell cycle control, p53, and DNA damage response protein expression in schizophrenia Stahl A, Heider J, Wüst R, Fallgatter AJ, Schenke-Layland K, Volkmer H, Templin MF. BMC Psychiatry. 2024 Oct 31;24(1):757. https://doi.org/10.1186/s12888-024-06127-x
Heterogeneity of Endothelial Cells Impacts the Functionality of Human Pancreatic In Vitro Models Urbanczyk M, Abuhelou A, Köninger M, Jeyagaran A, Carvajal-Berrio D, Kim E, Marzi J, Loskill P, Layland SL, Schenke-Layland K. Tissue Eng Part A. 2024 Oct 25. https://doi.org/10.1089/ten.tea.2024.0176
Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts Sigle M, Rohlfing AK, Cruz Santos M, Kopp T, Krutzke K, Gidlund V, Kollotzek F, Marzi J, von Ungern-Sternberg S, Poso A, Heikenwälder M, Schenke-Layland K, Seizer P, Möllmann J, Marx N, Feil R, Feil S, Lukowski R, Borst O, Schäffer TE, Müller KAL, Gawaz MP, Heinzmann D. Circ Res. 2024 Sep 13;135(7):758-773. https://doi.org/10.1161/CIRCRESAHA.124.324812
Metabolic syndrome-associated murine aortic wall stiffening is associated with premature elastic fibers aging Vanalderwiert L, Henry A, Wahart A, Carvajal Berrio DA, Brauchle EM, El Kaakour L, Schenke-Layland K, Brinckmann J, Steenbock H, Debelle L, Six I, Faury G, Jaisson S, Gillery P, Durlach V, Sartelet H, Maurice P, Bennasroune A, Martiny L, Duca L, Romier B, Blaise S. Am J Physiol Cell Physiol. 2024 Sep 1;327(3):C698-C715. https://doi.org/10.1152/ajpcell.00615.2023
Forward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafA Jeyagaran A, Urbanczyk M, Layland SL, Weise F, Schenke-Layland K. Sci Rep. 2024 Jun 13;14(1):13608. https://doi.org/10.1038/s41598-024-64346-4
MYCT1 controls environmental sensing in human haematopoietic stem cells Aguadé-Gorgorió J, Jami-Alahmadi Y, Calvanese V, Kardouh M, Fares I, Johnson H, Rezek V, Ma F, Magnusson M, Wang Y, Shin JE, Nance KJ, Goodridge HS, Liebscher S, Schenke-Layland K, Crooks GM, Wohlschlegel JA, Mikkola HKA. Nature. 2024 Jun;630(8016):412-420. https://doi.org/10.1038/s41586-024-07478-x
Characteristics Associated with COVID-19 Breakthrough Infections after Booster Vaccinations in Healthcare Workers: Insights from the TüSeRe:exact Study Uzun G, Bareiß A, Becker M, Althaus K, Dulovic A, Junker D, Schenke-Layland K, Martus P, Borst O, Schneiderhan-Marra N, Bakchoul T. J Clin Med. 2024 Mar 9;13(6):1571. https://doi.org/10.3390/jcm13061571
Human tissue-resident peritoneal macrophages reveal resistance towards oxidative cell stress induced by non-invasive physical plasma Schultze-Rhonhof L, Marzi J, Carvajal Berrio DA, Holl M, Braun T, Schäfer-Ruoff F, Andress J, Bachmann C, Templin M, Brucker SY, Schenke-Layland K, Weiss M. Front Immunol. 2024 Mar 5;15:1357340. https://doi.org/10.3389/fimmu.2024.1357340
Functionally-instructed modifiers of response to ATR inhibition in experimental glioma Walter B, Hirsch S, Kuhlburger L, Stahl A, Schnabel L, Wisser S, Haeusser LA, Tsiami F, Plöger S, Aghaallaei N, Dick AM, Skokowa J, Schmees C, Templin M, Schenke-Layland K, Tatagiba M, Nahnsen S, Merk DJ, Tabatabai G. J Exp Clin Cancer Res. 2024 Mar 12;43(1):77. https://doi.org/10.1186/s13046-024-02995-z
Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism Schlünder K, Cipriano M, Zbinden A, Fuchs S, Mayr T, Schenke-Layland K, Loskill P. Lab Chip. 2024 Mar 26;24(7):2080-2093. https://doi.org/10.1039/d3lc00838j
30 Years of Tissue Engineering Fisher JP, Mikos AG, Schenke-Layland K, Shin H, Jansen JA, Wang X. Tissue Eng Part A. 2024 Jan;30(1-2):3-4. https://doi.org/10.1089/ten.tea.2023.29053.joh
The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets Sleeboom JJF, van Tienderen GS, Schenke-Layland K, van der Laan LJW, Khalil AA, Verstegen MMA. Sci Transl Med. 2024 Jan 3;16(728):eadg3840. https://doi.org/10.1126/scitranslmed.adg3840
"Future Directions" - Novel breakthrough developments in the fields of drug development & delivery, and regenerative medicine Schenke-Layland K, MacKay A. Adv Drug Deliv Rev. 2024 Feb;205:115159. https://doi.org/10.1016/j.addr.2023.115159
On the reproducibility of extrusion-based bioprinting: round robin study on standardization in the field Grijalva Garces D, Strauß S, Gretzinger S, Schmieg B, Jüngst T, Groll J, Meinel L, Schmidt I, Hartmann H, Schenke-Layland K, Brandt N, Selzer M, Zimmermann S, Koltay P, Southan A, Tovar GEM, Schmidt S, Weber A, Ahlfeld T, Gelinsky M, Scheibel T, Detsch R, Boccaccini AR, Naolou T, Lee-Thedieck C, Willems C, Groth T, Allgeier S, Köhler B, Friedrich T, Briesen H, Buchholz J, Paulus D, von Gladiss A, Hubbuch J. Biofabrication. 2023 Oct 11;16(1). https://doi.org/10.1088/1758-5090/acfe3b
Translating genomic tools to Raman spectroscopy analysis enables high-dimensional tissue characterization on molecular resolution Sigle M, Rohlfing AK, Kenny M, Scheuermann S, Sun N, Graeßner U, Haug V, Sudmann J, Seitz CM, Heinzmann D, Schenke-Layland K, Maguire PB, Walch A, Marzi J, Gawaz MP. Nat Commun. 2023 Sep 19;14(1):5799. https://doi.org/10.1038/s41467-023-41417-0
Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment Anderle N, Schäfer-Ruoff F, Staebler A, Kersten N, Koch A, Önder C, Keller AL, Liebscher S, Hartkopf A, Hahn M, Templin M, Brucker SY, Schenke-Layland K, Schmees C. J Exp Clin Cancer Res. 2023 Aug 18;42(1):210. https://doi.org/10.1186/s13046-023-02782-2
Monitoring the macrophage response towards biomaterial implants using label-free imaging Lu CE, Levey RE, Ghersi G, Schueller N, Liebscher S, Layland SL, Schenke-Layland K, Duffy GP, Marzi J. Mater Today Bio. 2023 Jun 13;21:100696. https://doi.org/10.1016/j.mtbio.2023.100696
Exploring the relationship between epigenetic DNA methylation and cardiac fibrosis through Raman microspectroscopy Becker L, Montes-Mojarro IA, Layland SL, Nsair A, Fend F, Marzi J, Schenke-Layland K. Am J Physiol Cell Physiol. 2023 Jul 1;325(1):C332-C343. https://doi.org/10.1152/ajpcell.00209.2023
Raman microspectroscopy identifies fibrotic tissues in collagen-related disorders via deconvoluted collagen type I spectra Becker L, Lu CE, Montes-Mojarro IA, Layland SL, Khalil S, Nsair A, Duffy GP, Fend F, Marzi J, Schenke-Layland K. Acta Biomater. 2023 May;162:278-291. https://doi.org/10.1016/j.actbio.2023.03.016
The Use of Collagen-Based Materials in Bone Tissue Engineering Fan L, Ren Y, Emmert S, Vučković I, Stojanovic S, Najman S, Schnettler R, Barbeck M, Schenke-Layland K, Xiong X. Int J Mol Sci. 2023 Feb 13;24(4):3744. https://doi.org/10.3390/ijms24043744
Electrospinning of collagen: enzymatic and spectroscopic analyses reveal solvent-independent disruption of the triple-helical structure Visser D, Rogg K, Fuhrmann E, Marzi J, Schenke-Layland K, Hartmann H. J Mater Chem B. 2023 Mar 8;11(10):2207-2218. https://doi.org/10.1039/d2tb02602c
Vaccine Side Effects in Health Care Workers after Vaccination against SARS-CoV-2: Data from TüSeRe:exact Study Bareiß A, Uzun G, Mikus M, Becker M, Althaus K, Schneiderhan-Marra N, Fürstberger A, Schwab JD, Kestler HA, Holderried M, Martus P, Schenke-Layland K, Bakchoul T. Viruses. 2022 Dec 25;15(1):65. https://doi.org/10.3390/v15010065
Decorin improves human pancreatic β-cell function and regulates ECM expression in vitro Urbanczyk M, Jeyagaran A, Zbinden A, Lu CE, Marzi J, Kuhlburger L, Nahnsen S, Layland SL, Duffy G, Schenke-Layland K. Matrix Biol. 2023 Jan;115:160-183. https://doi.org/10.1016/j.matbio.2022.12.005
Generation and characterization of three induced pluripotent stem cells lines from an 86-year old female individual diagnosed with an invasive lobular mammary carcinoma Keller AL, Greis D, Eybe J, Plöger S, Weiss M, Koch A, Brucker SY, Schenke-Layland K, Schmees C. Stem Cell Res. 2023 Feb;66:102988. https://doi.org/10.1016/j.scr.2022.102988
Green Chemistry for Biomimetic Materials: Synthesis and Electrospinning of High-Molecular-Weight Polycarbonate-Based Nonisocyanate Polyurethanes Visser D, Bakhshi H, Rogg K, Fuhrmann E, Wieland F, Schenke-Layland K, Meyer W, Hartmann H. ACS Omega. 2022 Oct 26;7(44):39772-39781. https://doi.org/10.1021/acsomega.2c03731
Protein Profiling of Breast Carcinomas Reveals Expression of Immune-Suppressive Factors and Signatures Relevant for Patient Outcome Ruoff F, Kersten N, Anderle N, Jerbi S, Stahl A, Koch A, Staebler A, Hartkopf A, Brucker SY, Hahn M, Schenke-Layland K, Schmees C, Templin MF. Cancers (Basel). 2022 Sep 19;14(18):4542. https://doi.org/10.3390/cancers14184542
Establishment of Four Induced Pluripotent Stem Cell Lines from CD34+ Hematopoietic Stem and Progenitor Cells from a Patient Diagnosed with an Invasive Lobular Mammary Carcinoma Keller AL, Binner A, Schenke-Layland K, Schmees C. Stem Cell Res. 2022 Oct;64:102902. https://doi.org/10.1016/j.scr.2022.102902
A Platform of Patient-Derived Microtumors Identifies Individual Treatment Responses and Therapeutic Vulnerabilities in Ovarian Cancer Anderle N, Koch A, Gierke B, Keller AL, Staebler A, Hartkopf A, Brucker SY, Pawlak M, Schenke-Layland K, Schmees C. Cancers (Basel). 2022 Jun 12;14(12):2895. https://doi.org/10.3390/cancers14122895
Antibody Binding and Angiotensin-Converting Enzyme 2 Binding Inhibition Is Significantly Reduced for Both the BA.1 and BA.2 Omicron Variants Junker D, Becker M, Wagner TR, Kaiser PD, Maier S, Grimm TM, Griesbaum J, Marsall P, Gruber J, Traenkle B, Heinzel C, Pinilla YT, Held J, Fendel R, Kreidenweiss A, Nelde A, Maringer Y, Schroeder S, Walz JS, Althaus K, Uzun G, Mikus M, Bakchoul T, Schenke-Layland K, Bunk S, Haeberle H, Göpel S, Bitzer M, Renk H, Remppis J, Engel C, Franz AR, Harries M, Kessel B, Lange B, Strengert M, Krause G, Zeck A, Rothbauer U, Dulovic A, Schneiderhan-Marra N. Clin Infect Dis. 2023 Feb 8;76(3):e240-e249. https://doi.org/10.1093/cid/ciac498
Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation Brandhorst D, Brandhorst H, Lee Layland S, Acreman S, Schenke-Layland K, Johnson PRV. Acta Biomater. 2022 Jan 1;137:92-102. https://doi.org/10.1016/j.actbio.2021.10.013
Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone Jiménez-Altayó F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke-Layland K, Jiménez-Xarrié E, Planas AM. J Cereb Blood Flow Metab. 2022 Jan;42(1):162-174. https://doi.org/10.1177/0271678X211033362
Mapping human haematopoietic stem cells from haemogenic endothelium to birth Calvanese V, Capellera-Garcia S, Ma F, Fares I, Liebscher S, Ng ES, Ekstrand S, Aguadé-Gorgorió J, Vavilina A, Lefaudeux D, Nadel B, Li JY, Wang Y, Lee LK, Ardehali R, Iruela-Arispe ML, Pellegrini M, Stanley EG, Elefanty AG, Schenke-Layland K, Mikkola HKA. Nature. 2022 Apr;604(7906):534-540. https://doi.org/10.1038/s41586-022-04571-x
Raman Microspectroscopy Identifies Biochemical Activation Fingerprints in THP-1- and PBMC-Derived Macrophages Feuerer N, Carvajal Berrio DA, Billing F, Segan S, Weiss M, Rothbauer U, Marzi J, Schenke-Layland K. Biomedicines. 2022 Apr 25;10(5):989. https://doi.org/10.3390/biomedicines10050989
Marker-Independent Monitoring of in vitro and in vivo Degradation of Supramolecular Polymers Applied in Cardiovascular in situ Tissue Engineering Marzi J, Munnig Schmidt EC, Brauchle EM, Wissing TB, Bauer H, Serrero A, Söntjens SHM, Bosman AW, Cox MAJ, Smits AIPM, Schenke-Layland K. Front Cardiovasc Med. 2022 May 17;9:885873. https://doi.org/10.3389/fcvm.2022.885873
Data-Driven Identification of Biomarkers for In Situ Monitoring of Drug Treatment in Bladder Cancer Organoids Becker L, Fischer F, Fleck JL, Harland N, Herkommer A, Stenzl A, Aicher WK, Schenke-Layland K, Marzi J. Int J Mol Sci. 2022 Jun 23;23(13):6956. https://doi.org/10.3390/ijms23136956
Type 1 diabetes and engineering enhanced islet transplantation Jeyagaran A, Lu CE, Zbinden A, Birkenfeld AL, Brucker SY, Layland SL. Adv Drug Deliv Rev. 2022 Oct;189:114481. https://doi.org/10.1016/j.addr.2022.114481
Organ-specific endothelial cell heterogenicity and its impact on regenerative medicine and biomedical engineering applications Urbanczyk M, Zbinden A, Schenke-Layland K. Adv Drug Deliv Rev. 2022 Jul;186:114323. https://doi.org/10.1016/j.addr.2022.114323
Autologous Human Immunocompetent White Adipose Tissue-on-Chip Rogal J, Roosz J, Teufel C, Cipriano M, Xu R, Eisler W, Weiss M, Schenke-Layland K, Loskill P. Adv Sci (Weinh). 2022 Jun;9(18):e2104451. https://doi.org/10.1002/advs.202104451
Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia Marzi J, Stope MB, Henes M, Koch A, Wenzel T, Holl M, Layland SL, Neis F, Bösmüller H, Ruoff F, Templin M, Krämer B, Staebler A, Barz J, Carvajal Berrio DA, Enderle M, Loskill PM, Brucker SY, Schenke-Layland K, Weiss M. Cancers (Basel). 2022 Apr 12;14(8):1933. https://doi.org/10.3390/cancers14081933
Cell Type-Specific Anti-Adhesion Properties of Peritoneal Cell Treatment with Plasma-Activated Media (PAM) Holl M, Rasch ML, Becker L, Keller AL, Schultze-Rhonhof L, Ruoff F, Templin M, Keller S, Neis F, Keßler F, Andress J, Bachmann C, Krämer B, Schenke-Layland K, Brucker SY, Marzi J, Weiss M. Biomedicines. 2022 Apr 18;10(4):927. https://doi.org/10.3390/biomedicines10040927
Lipidome profiling with Raman microspectroscopy identifies macrophage response to surface topographies of implant materials Feuerer N, Marzi J, Brauchle EM, Carvajal Berrio DA, Billing F, Weiss M, Jakobi M, Schneiderhan-Marra N, Shipp C, Schenke-Layland K. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2113694118. https://doi.org/10.1073/pnas.2113694118
Development of a bi-layered cryogenic electrospun polylactic acid scaffold to study calcific aortic valve disease in a 3D co-culture model Stadelmann K, Weghofer A, Urbanczyk M, Maulana TI, Loskill P, Jones PD, Schenke-Layland K. Acta Biomater. 2022 Mar 1;140:364-378. https://doi.org/10.1016/j.actbio.2021.11.030
Raman Imaging and Fluorescence Lifetime Imaging Microscopy for Diagnosis of Cancer State and Metabolic Monitoring Becker L, Janssen N, Layland SL, Mürdter TE, Nies AT, Schenke-Layland K, Marzi J. Cancers (Basel). 2021 Nov 13;13(22):5682. https://doi.org/10.3390/cancers13225682
Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model Armento A, Murali A, Marzi J, Almansa-Garcia AC, Arango-Gonzalez B, Kilger E, Clark SJ, Schenke-Layland K, Ramlogan-Steel CA, Steel JC, Ueffing M. Biomolecules. 2021 Nov 3;11(11):1621. https://doi.org/10.3390/biom11111621
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes Petrigliano FA, Liu NQ, Lee S, Tassey J, Sarkar A, Lin Y, Li L, Yu Y, Geng D, Zhang J, Shkhyan R, Bogdanov J, Van Handel B, Ferguson GB, Lee Y, Hinderer S, Tseng KC, Kavanaugh A, Crump JG, Pyle AD, Schenke-Layland K, Billi F, Wang L, Lieberman J, Hurtig M, Evseenko D. NPJ Regen Med. 2021 Nov 23;6(1):77. https://doi.org/10.1038/s41536-021-00187-3
Three Water Restriction Schedules Used in Rodent Behavioral Tasks Transiently Impair Growth and Differentially Evoke a Stress Hormone Response without Causing Dehydration Vasilev D, Havel D, Liebscher S, Slesiona-Kuenzel S, Logothetis NK, Schenke-Layland K, Totah NK. eNeuro. 2021 Dec 14;8(6):ENEURO.0424-21.2021. https://doi.org/10.1523/ENEURO.0424-21.2021
Hyaluronic Acid-Functionalized Hybrid Gelatin-Poly-L-Lactide Scaffolds with Tunable Hydrophilicity Piccirillo G, Feuerer N, Carvajal Berrio DA, Layland SL, Reimer Hinderer S, Bochicchio B, Schenke-Layland K. Tissue Eng Part C Methods. 2021 Nov;27(11):589-604. https://doi.org/10.1089/ten.TEC.2021.0178
Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation Brandhorst D, Brandhorst H, Lee Layland S, Acreman S, Schenke-Layland K, Johnson PRV. Acta Biomater. 2022 Jan 1;137:92-102. https://doi.org/10.1016/j.actbio.2021.10.013
Imaging of α-Synuclein Aggregates in a Rat Model of Parkinson's Disease Using Raman Microspectroscopy Sevgi F, Brauchle EM, Carvajal Berrio DA, Schenke-Layland K, Casadei N, Salker MS, Riess O, Singh Y. Front Cell Dev Biol. 2021 Sep 10;9:664365. https://doi.org/10.3389/fcell.2021.664365
The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model Beatty R, Lu CE, Marzi J, Levey RE, Carvajal Berrio D, Lattanzi G, Wylie R, O'Connor R, Wallace E, Ghersi G, Salamone M, Dolan EB, Layland SL, Schenke-Layland K, Duffy GP. Tissue Eng Part C Methods. 2021 Oct;27(10):515-528. https://doi.org/10.1089/ten.TEC.2021.0163
Distinct Effects of Heparin and Interleukin-4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats Bonito V, Koch SE, Krebber MM, Carvajal-Berrio DA, Marzi J, Duijvelshoff R, Lurier EB, Buscone S, Dekker S, de Jong SMJ, Mes T, Vaessen KRD, Brauchle EM, Bosman AW, Schenke-Layland K, Verhaar MC, Dankers PYW, Smits AIPM, Bouten CVC. Adv Healthc Mater. 2021 Nov;10(21):e2101103. https://doi.org/10.1002/adhm.202101103
Inflammatory and regenerative processes in bioresorbable synthetic pulmonary valves up to two years in sheep-Spatiotemporal insights augmented by Raman microspectroscopy De Kort BJ, Marzi J, Brauchle EM, Lichauco AM, Bauer HS, Serrero A, Dekker S, Cox MAJ, Schoen FJ, Schenke-Layland K, Bouten CVC, Smits AIPM. Acta Biomater. 2021 Nov;135:243-259. https://doi.org/10.1016/j.actbio.2021.09.005
Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone Jiménez-Altayó F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke-Layland K, Jiménez-Xarrié E, Planas AM. J Cereb Blood Flow Metab. 2022 Jan;42(1):162-174. https://doi.org/10.1177/0271678X211033362
Organoids for the advancement of intraoperative diagnostic procedures Harland N, Amend B, Lipke N, Brucker SY, Fend F, Herkommer A, Lensch H, Sawodny O, Schäffer TE, Schenke-Layland K, Tarín Sauer C, Aicher W, Stenzl A. Urologe A. 2021 Sep;60(9):1159-1166. https://doi.org/10.1007/s00120-021-01595-5
Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms Sugiyama K, Marzi J, Alber J, Brauchle EM, Ando M, Yamashiro Y, Ramkhelawon B, Schenke-Layland K, Yanagisawa H. Cell Rep Med. 2021 Apr 28;2(5):100261. https://doi.org/10.1016/j.xcrm.2021.100261
Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration Zbinden A, Layland SL, Urbanczyk M, Carvajal Berrio DA, Marzi J, Zauner M, Hammerschmidt A, Brauchle EM, Sudrow K, Fink S, Templin M, Liebscher S, Klein G, Deb A, Duffy GP, Crooks GM, Eble JA, Mikkola HKA, Nsair A, Seifert M, Schenke-Layland K. Adv Sci (Weinh). 2020 Dec 21;8(4):2002500. https://doi.org/10.1002/advs.202002500
Laparoscopic Peritoneal Wash Cytology-Derived Primary Human Mesothelial Cells for In Vitro Cell Culture and Simulation of Human Peritoneum Holl M, Becker L, Keller AL, Feuerer N, Marzi J, Carvajal Berrio DA, Jakubowski P, Neis F, Pauluschke-Fröhlich J, Brucker SY, Schenke-Layland K, Krämer B, Weiss M. Biomedicines. 2021 Feb 10;9(2):176. https://doi.org/10.3390/biomedicines9020176
Human heart-forming organoids recapitulate early heart and foregut development Drakhlis L, Biswanath S, Farr CM, Lupanow V, Teske J, Ritzenhoff K, Franke A, Manstein F, Bolesani E, Kempf H, Liebscher S, Schenke-Layland K, Hegermann J, Nolte L, Meyer H, de la Roche J, Thiemann S, Wahl-Schott C, Martin U, Zweigerdt R. Nat Biotechnol. 2021 Jun;39(6):737-746. https://doi.org/10.1038/s41587-021-00815-9
Elastin-like hydrogel stimulates angiogenesis in a severe model of critical limb ischemia (CLI): An insight into the glyco-host response Marsico G, Jin C, Abbah SA, Brauchle EM, Thomas D, Rebelo AL, Orbanić D, Chantepie S, Contessotto P, Papy-Garcia D, Rodriguez-Cabello C, Kilcoyne M, Schenke-Layland K, Karlsson NG, McCullagh KJA, Pandit A. Biomaterials. 2021 Feb;269:120641. https://doi.org/10.1016/j.biomaterials.2020.120641
Fibronectin adsorption on oxygen plasma-treated polyurethane surfaces modulates endothelial cell response Daum R, Mrsic I, Hutterer J, Junginger A, Hinderer S, Meixner AJ, Gauglitz G, Chassé T, Schenke-Layland K. J Mater Chem B. 2021 Feb 14;9(6):1647-1660. https://doi.org/10.1039/d0tb02757j
Macrophage retrival from 3D biomaterials: A detailed comparison of common dissociation methods Feuerer N, Morschl J, Daum R, Weiss M, Hinderer S, Schenke-Layland K, Shipp C. J Immunol Regen Med 2021 in press. https://doi.org/10.1016/j.regen.2020.100035
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation Chitiashvili T, Dror I, Kim R, Hsu FM, Chaudhari R, Pandolfi E, Chen D, Liebscher S, Schenke-Layland K, Plath K, Clark A. Nat Cell Biol. 2020 Dec;22(12):1436-1446. https://doi.org/10.1038/s41556-020-00607-4
Fluorescence lifetime metabolic mapping of hypoxia-induced damage in pancreatic pseudo-islets Zbinden A, Carvajal Berrio DA, Urbanczyk M, Layland SL, Bosch M, Fliri S, Lu CE, Jeyagaran A, Loskill P, Duffy GP, Schenke-Layland K. J Biophotonics. 2020 Dec;13(12):e202000375. https://doi.org/10.1002/jbio.202000375
Collagen and Endothelial Cell Coculture Improves β-Cell Functionality and Rescues Pancreatic Extracellular Matrix Zbinden A, Urbanczyk M, Layland SL, Becker L, Marzi J, Bosch M, Loskill P, Duffy GP, Schenke-Layland K. Tissue Eng Part A. 2020 Nov 6. https://doi.org/10.1089/ten.TEA.2020.0250
A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells Xi H, Langerman J, Sabri S, Chien P, Young CS, Younesi S, Hicks M, Gonzalez K, Fujiwara W, Marzi J, Liebscher S, Spencer M, Van Handel B, Evseenko D, Schenke-Layland K, Plath K, Pyle AD. Cell Stem Cell. 2020 Jul 2;27(1):181-185. https://doi.org/10.1016/j.stem.2020.06.006
Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma Spenlé C, Loustau T, Murdamoothoo D, Erne W, Beghelli-de la Forest Divonne S, Veber R, Petti L, Bourdely P, Mörgelin M, Brauchle EM, Cremel G, Randrianarisoa V, Camara A, Rekima S, Schaub S, Nouhen K, Imhof T, Hansen U, Paul N, Carapito R, Pythoud N, Hirschler A, Carapito C, Dumortier H, Mueller CG, Koch M, Schenke-Layland K, Kon S, Sudaka A, Anjuère F, Van Obberghen-Schilling E, Orend G. Cancer Immunol Res. 2020 Sep;8(9):1122-1138. https://doi.org/10.1158/2326-6066.CIR-20-0074
HepaChip-MP - a twenty-four chamber microplate for a continuously perfused liver coculture model Busche M, Tomilova O, Schütte J, Werner S, Beer M, Groll N, Hagmeyer B, Pawlak M, Jones PD, Schmees C, Becker H, Schnabel J, Gall K, Hemmler R, Matz-Soja M, Damm G, Beuck S, Klaassen T, Moer J, Ullrich A, Runge D, Schenke-Layland K, Gebhardt R, Stelzle M. Lab Chip. 2020 Aug 11;20(16):2911-2926. https://doi.org/10.1039/d0lc00357c
WAT-on-a-chip integrating human mature white adipocytes for mechanistic research and pharmaceutical applications Rogal J, Binder C, Kromidas E, Roosz J, Probst C, Schneider S, Schenke-Layland K, Loskill P. Sci Rep. 2020 Apr 20;10(1):6666. https://doi.org/10.1038/s41598-020-63710-4
Fibronectin Adsorption on Electrospun Synthetic Vascular Grafts Attracts Endothelial Progenitor Cells and Promotes Endothelialization in Dynamic In Vitro Culture Daum R, Visser D, Wild C, Kutuzova L, Schneider M, Lorenz G, Weiss M, Hinderer S, Stock UA, Seifert M, Schenke-Layland K. Cells. 2020 Mar 23;9(3):778. https://doi.org/10.3390/cells9030778
Trans-Mucosal Efficacy of Non-Thermal Plasma Treatment on Cervical Cancer Tissue and Human Cervix Uteri by a Next Generation Electrosurgical Argon Plasma Device Wenzel T, Carvajal Berrio DA, Reisenauer C, Layland S, Koch A, Wallwiener D, Brucker SY, Schenke-Layland K, Brauchle EM, Weiss M. Cancers (Basel). 2020 Jan 22;12(2):267. https://doi.org/10.3390/cancers12020267
The role of extracellular matrix in biomechanics and its impact on bioengineering of cells and 3D tissues Urbanczyk M, Layland SL, Schenke-Layland K. Matrix Biol. 2020 Jan;85-86:1-14. https://doi.org/10.1016/j.matbio.2019.11.005
Towards automation in biologics production via Raman micro-spectroscopy, laser-induced forward cell transfer and surface-enhanced Raman spectroscopy Jaeckle E, Brauchle E, Nottrodt N, Wehner M, Lensing R, Gillner A, Schenke-Layland K, Bach M, Burger-Kentischer A. J Biotechnol. 2020 Nov 10;323:313-321. https://doi.org/10.1016/j.jbiotec.2020.09.001
Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study Guo S, Beleites C, Neugebauer U, Abalde-Cela S, Afseth NK, Alsamad F, Anand S, Araujo-Andrade C, Aškrabić S, Avci E, Baia M, Baranska M, Baria E, Batista de Carvalho LAE, de Bettignies P, Bonifacio A, Bonnier F, Brauchle EM, Byrne HJ, Chourpa I, Cicchi R, Cuisinier F, Culha M, Dahms M, David C, Duponchel L, Duraipandian S, El-Mashtoly SF, Ellis DI, Eppe G, Falgayrac G, Gamulin O, Gardner B, Gardner P, Gerwert K, Giamarellos-Bourboulis EJ, Gizurarson S, Gnyba M, Goodacre R, Grysan P, Guntinas-Lichius O, Helgadottir H, Grošev VM, Kendall C, Kiselev R, Kölbach M, Krafft C, Krishnamoorthy S, Kubryck P, Lendl B, Loza-Alvarez P, Lyng FM, Machill S, Malherbe C, Marro M, Marques MPM, Matuszyk E, Morasso CF, Moreau M, Muhamadali H, Mussi V, Notingher I, Pacia MZ, Pavone FS, Penel G, Petersen D, Piot O, Rau JV, Richter M, Rybarczyk MK, Salehi H, Schenke-Layland K, Schlücker S, Schosserer M, Schütze K, Sergo V, Sinjab F, Smulko J, Sockalingum GD, Stiebing C, Stone N, Untereiner V, Vanna R, Wieland K, Popp J, Bocklitz T. Anal Chem. 2020 Dec 15;92(24):15745-15756. https://doi.org/10.1021/acs.analchem.0c02696
Advanced drug delivery 2020 - Parts 1,2 and 3 Ghandehari H, Chan HK, Harashima H, MacKay JA, Minko T, Schenke-Layland K, Shen Y, Vicent MJ. Adv Drug Deliv Rev. 2020;156:1-2. https://doi.org/10.1016/j.addr.2020.11.003
Controlled Heterotypic Pseudo-Islet Assembly of Human β-Cells and Human Umbilical Vein Endothelial Cells Using Magnetic Levitation Urbanczyk M, Zbinden A, Layland SL, Duffy G, Schenke-Layland K. Tissue Eng Part A. 2020 Apr;26(7-8):387-399. https://doi.org/10.1089/ten.TEA.2019.0158
Molecular Effects and Tissue Penetration Depth of Physical Plasma in Human Mucosa Analyzed by Contact- and Marker-Independent Raman Microspectroscopy Wenzel T, Carvajal Berrio DA, Daum R, Reisenauer C, Weltmann KD, Wallwiener D, Brucker SY, Schenke-Layland K, Brauchle EM, Weiss M. ACS Appl Mater Interfaces. 2019 Nov 20;11(46):42885-42895. https://doi.org/10.1021/acsami.9b13221
Hyaluronic acid as a macromolecular crowding agent for production of cell-derived matrices Shendi D, Marzi J, Linthicum W, Rickards AJ, Dolivo DM, Keller S, Kauss MA, Wen Q, McDevitt TC, Dominko T, Schenke-Layland K, Rolle MW. Acta Biomater. 2019 Dec;100:292-305. https://doi.org/10.1016/j.actbio.2019.09.042
Donor age significantly influences the Raman spectroscopic biomolecular fingerprint of human pancreatic extracellular matrix proteins following collagenase-based digestion Spiers RM, Marzi J, Brauchle EM, Cross SE, Vaughan RH, Bateman PA, Hughes SJ, Schenke-Layland K, Johnson PRV. Acta Biomater. 2019 Nov;99:269-283. https://doi.org/10.1016/j.actbio.2019.09.013
Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform Achberger K, Probst C, Haderspeck J, Bolz S, Rogal J, Chuchuy J, Nikolova M, Cora V, Antkowiak L, Haq W, Shen N, Schenke-Layland K, Ueffing M, Liebau S, Loskill P. Elife. 2019 Aug 27;8:e46188. https://doi.org/10.7554/eLife.46188
A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction Dolan EB, Hofmann B, de Vaal MH, Bellavia G, Straino S, Kovarova L, Pravda M, Velebny V, Daro D, Braun N, Monahan DS, Levey RE, O'Neill H, Hinderer S, Greensmith R, Monaghan MG, Schenke-Layland K, Dockery P, Murphy BP, Kelly HM, Wildhirt S, Duffy GP. Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109751. https://doi.org/10.1016/j.msec.2019.109751
Imaging fibrosis in inflammatory diseases: targeting the exposed extracellular matrix Beziere N, Fuchs K, Maurer A, Reischl G, Brück J, Ghoreschi K, Fehrenbacher B, Berrio DC, Schenke-Layland K, Kohlhofer U, Quintanilla-Martinez L, Gawaz M, Kneilling M, Pichler B. Theranostics. 2019 Apr 13;9(10):2868-2881. https://doi.org/10.7150/thno.28892
Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model Zbinden A, Marzi J, Schlünder K, Probst C, Urbanczyk M, Black S, Brauchle EM, Layland SL, Kraushaar U, Duffy G, Schenke-Layland K, Loskill P. Matrix Biol. 2020 Jan;85-86:205-220. https://doi.org/10.1016/j.matbio.2019.06.008
Cardiac fibrosis - A short review of causes and therapeutic strategies Hinderer S, Schenke-Layland K. Adv Drug Deliv Rev. 2019 Jun;146:77-82. https://doi.org/10.1016/j.addr.2019.05.011
Why, When, Who, What, How, and Where for Trainees Writing Literature Review Articles Koons GL, Schenke-Layland K, Mikos AG. Ann Biomed Eng. 2019 Nov;47(11):2334-2340. https://doi.org/10.1007/s10439-019-02290-5
Dose-Dependent Tissue-Level Characterization of a Medical Atmospheric Pressure Argon Plasma Jet Weiss M, Barz J, Ackermann M, Utz R, Ghoul A, Weltmann KD, Stope MB, Wallwiener D, Schenke-Layland K, Oehr C, Brucker S, Loskill P. ACS Appl Mater Interfaces. 2019 Jun 5;11(22):19841-19853. https://doi.org/10.1021/acsami.9b04803
Non-invasive detection of DNA methylation states in carcinoma and pluripotent stem cells using Raman microspectroscopy and imaging Daum R, Brauchle EM, Berrio DAC, Jurkowski TP, Schenke-Layland K. Sci Rep. 2019 May 7;9(1):7014. https://doi.org/10.1038/s41598-019-43520-z
Non-invasive functional molecular phenotyping of human smooth muscle cells utilized in cardiovascular tissue engineering Marzi J, Brauchle EM, Schenke-Layland K, Rolle MW. Acta Biomater. 2019 Apr 15;89:193-205. https://doi.org/10.1016/j.actbio.2019.03.026
Controlled and tuneable drug release from electrospun fibers and a non-invasive approach for cytotoxicity testing Piccirillo G, Carvajal Berrio DA, Laurita A, Pepe A, Bochicchio B, Schenke-Layland K, Hinderer S. Sci Rep. 2019 Mar 5;9(1):3446. https://doi.org/10.1038/s41598-019-40079-7
Marker-Independent In Situ Quantitative Assessment of Residual Cryoprotectants in Cardiac Tissues Marzi J, Biermann AC, Brauchle EM, Brockbank KGM, Stock UA, Schenke-Layland K. Anal Chem. 2019 Feb 5;91(3):2266-2272. https://doi.org/10.1021/acs.analchem.8b04861
Comparative Study of MSCA-1 and CD146 Isolated Periosteal Cell Subpopulations Umrath F, Thomalla C, Pöschel S, Schenke-Layland K, Reinert S, Alexander D. Cell Physiol Biochem. 2018;51(3):1193-1206. https://doi.org/10.1159/000495497
Non-invasive characterization of hybrid gelatin:poly-l-lactide electrospun scaffolds using second harmonic generation and multiphoton imaging Piccirillo G , Ditaranto MV , Feuerer NFS , Carvajal Berrio DA , Brauchle EM , Pepe A , Bochicchio B , Schenke-Layland K , Hinderer S . J Mater Chem B. 2018 Oct 28;6(40):6399-6412. https://doi.org/10.1039/c8tb02026d
Stem-cell based organ-on-a-chip models for diabetes research Rogal J, Zbinden A, Schenke-Layland K, Loskill P. Adv Drug Deliv Rev. 2019 Feb 1;140:101-128. https://doi.org/10.1016/j.addr.2018.10.010
Improved long-term durability of allogeneic heart valves in the orthotopic sheep model Biermann AC, Marzi J, Brauchle E, Wichmann JL, Arendt CT, Puntmann V, Nagel E, Abdelaziz S, Winter AG, Brockbank KGM, Layland S, Schenke-Layland K, Stock UA. Eur J Cardiothorac Surg. 2019 Mar 1;55(3):484-493. https://doi.org/10.1093/ejcts/ezy292
Influence of aflibercept on platelet activation profile Sobolewska B, Golenko J, Poeschel S, Grimmel C, Gatsiou A, Sopova K, Biedermann T, Schenke-Layland K, Stellos K, Ziemssen F. Exp Eye Res. 2018 Oct;175:166-172. https://doi.org/10.1016/j.exer.2018.06.009
Biomechanical and biomolecular characterization of extracellular matrix structures in human colon carcinomas Brauchle E, Kasper J, Daum R, Schierbaum N, Falch C, Kirschniak A, Schäffer TE, Schenke-Layland K. Matrix Biol. 2018 Aug;68-69:180-193. https://doi.org/10.1016/j.matbio.2018.03.016
Electroconductive Biohybrid Collagen/Pristine Graphene Composite Biomaterials with Enhanced Biological Activity Ryan AJ, Kearney CJ, Shen N, Khan U, Kelly AG, Probst C, Brauchle E, Biccai S, Garciarena CD, Vega-Mayoral V, Loskill P, Kerrigan SW, Kelly DJ, Schenke-Layland K, Coleman JN, O'Brien FJ. Adv Mater. 2018 Apr;30(15):e1706442. https://doi.org/10.1002/adma.201706442
Surface functionalization of electrospun scaffolds using recombinant human decorin attracts circulating endothelial progenitor cells Hinderer S, Sudrow K, Schneider M, Holeiter M, Layland SL, Seifert M, Schenke-Layland K. Sci Rep. 2018 Jan 8;8(1):110. https://doi.org/10.1038/s41598-017-18382-y
Impact of T-cell-mediated immune response on xenogeneic heart valve transplantation: short-term success and mid-term failure Biermann AC, Marzi J, Brauchle E, Schneider M, Kornberger A, Abdelaziz S, Wichmann JL, Arendt CT, Nagel E, Brockbank KGM, Seifert M, Schenke-Layland K, Stock UA. Eur J Cardiothorac Surg. 2018 Apr 1;53(4):784-792. https://doi.org/10.1093/ejcts/ezx396
A flow bioreactor system compatible with real-time two-photon fluorescence lifetime imaging microscopy Shen N, Riedl JA, Carvajal Berrio DA, Davis Z, Monaghan MG, Layland SL, Hinderer S, Schenke-Layland K. Biomed Mater. 2018 Feb 2;13(2):024101. https://doi.org/10.1088/1748-605X/aa9b3c
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease Fitzgerald JC, Zimprich A, Carvajal Berrio DA, Schindler KM, Maurer B, Schulte C, Bus C, Hauser AK, Kübler M, Lewin R, Bobbili DR, Schwarz LM, Vartholomaiou E, Brockmann K, Wüst R, Madlung J, Nordheim A, Riess O, Martins LM, Glaab E, May P, Schenke-Layland K, Picard D, Sharma M, Gasser T, Krüger R. Brain. 2017 Sep 1;140(9):2444-2459. https://doi.org/10.1093/brain/awx202
Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Cell Rep. 2017 Oct 10;21(2):517-532. https://doi.org/10.1016/j.celrep.2017.09.047
Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, Pöschel S, Layland SL, Holeiter M, Knolle S, Brauchle E, Nsair A, Hinderer S, Schenke-Layland K. Stem Cell Reports. 2017 Jul 11;9(1):122-135. https://doi.org/10.1016/j.stemcr.2017.04.021
Exogenous miR-29B Delivery Through a Hyaluronan-Based Injectable System Yields Functional Maintenance of the Infarcted Myocardium Monaghan MG, Holeiter M, Brauchle E, Layland SL, Lu Y, Deb A, Pandit A, Nsair A, Schenke-Layland K. Tissue Eng Part A. 2018 Jan;24(1-2):57-67. https://doi.org/10.1089/ten.TEA.2016.0527
Raman Spectroscopic Analyses of Jaw Periosteal Cell Mineralization Brauchle E, Carvajal Berrio D, Rieger M, Schenke-Layland K, Reinert S, Alexander D. Stem Cells Int. 2017;2017:1651376. https://doi.org/10.1155/2017/1651376
Applying phasor approach analysis of multiphoton FLIM measurements to probe the metabolic activity of three-dimensional in vitro cell culture models Lakner PH, Monaghan MG, Möller Y, Olayioye MA, Schenke-Layland K. Sci Rep. 2017 Feb 13;7:42730. https://doi.org/10.1038/srep42730
In Vivo Human Somitogenesis Guides Somite Development from hPSCs Xi H, Fujiwara W, Gonzalez K, Jan M, Liebscher S, Van Handel B, Schenke-Layland K, Pyle AD. Cell Rep. 2017 Feb 7;18(6):1573-1585. https://doi.org/10.1016/j.celrep.2017.01.040
Enhanced elastin synthesis and maturation in human vascular smooth muscle tissue derived from induced-pluripotent stem cells Eoh JH, Shen N, Burke JA, Hinderer S, Xia Z, Schenke-Layland K, Gerecht S. Acta Biomater. 2017 Apr 1;52:49-59. https://doi.org/10.1016/j.actbio.2017.01.083
Allograft Heart Valves: Current Aspects and Future Applications Lisy M, Kalender G, Schenke-Layland K, Brockbank KG, Biermann A, Stock UA. Biopreserv Biobank. 2017 Apr;15(2):148-157. https://doi.org/10.1089/bio.2016.0070
Raman microspectroscopy as a diagnostic tool for the non-invasive analysis of fibrillin-1 deficiency in the skin and in the in vitro skin models Brauchle E, Bauer H, Fernes P, Zuk A, Schenke-Layland K, Sengle G. Acta Biomater. 2017 Apr 1;52:41-48. https://doi.org/10.1016/j.actbio.2016.12.019
Electrospun poly-l-lactide scaffold for the controlled and targeted delivery of a synthetically obtained Diclofenac prodrug to treat actinic keratosis Piccirillo G, Bochicchio B, Pepe A, Schenke-Layland K, Hinderer S. Acta Biomater. 2017 Apr 1;52:187-196. https://doi.org/10.1016/j.actbio.2016.11.002
Differentiation of human embryonic stem cells to HOXA(+) hemogenic vasculature that resembles the aorta-gonad-mesonephros Ng ES, Azzola L, Bruveris FF, Calvanese V, Phipson B, Vlahos K, Hirst C, Jokubaitis VJ, Yu QC, Maksimovic J, Liebscher S, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock DN, Nilsson SK, Saffery R, Schenke-Layland K, Oshlack A, Mikkola HK, Stanley EG, Elefanty AG. Nat Biotechnol. 2016 Nov;34(11):1168-1179. https://doi.org/10.1038/nbt.3702
Raman microspectroscopy for the development and screening of recombinant cell lines Brauchle E, Schenke-Layland K. Biotechnol J. 2017 Jan;12(1). https://doi.org/10.1002/biot.201600412
Mononuclear phagocytes contribute to intestinal invasion and dissemination of Yersinia enterocolitica Drechsler-Hake D, Alamir H, Hahn J, Günter M, Wagner S, Schütz M, Bohn E, Schenke-Layland K, Pisano F, Dersch P, Autenrieth IB, Autenrieth SE. Int J Med Microbiol. 2016 Sep;306(6):357-66. https://doi.org/10.1016/j.ijmm.2016.04.002
Enabling Multiphoton and Second Harmonic Generation Imaging in Paraffin-Embedded and Histologically Stained Sections Monaghan MG, Kroll S, Brucker SY, Schenke-Layland K. Tissue Eng Part C Methods. 2016 Jun;22(6):517-23. https://doi.org/10.1089/ten.TEC.2016.0071
Cardiomyocyte generation from somatic sources - current status and future directions Monaghan MG, Holeiter M, Layland SL, Schenke-Layland K. Curr Opin Biotechnol. 2016 Aug;40:49-55. https://doi.org/10.1016/j.copbio.2016.02.014
Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology Felka T, Rothdiener M, Bast S, Uynuk-Ool T, Zouhair S, Ochs BG, De Zwart P, Stoeckle U, Aicher WK, Hart ML, Shiozawa T, Grodzinsky AJ, Schenke-Layland K, Venkatesan JK, Cucchiarini M, Madry H, Kurz B, Rolauffs B. Osteoarthritis Cartilage. 2016 Jul;24(7):1200-9. https://doi.org/10.1016/j.joca.2016.02.001
Visualizing tropoelastin in a long-term human elastic fibre cell culture model Halm M, Schenke-Layland K, Jaspers S, Wenck H, Fischer F. Sci Rep. 2016 Feb 4;6:20378. https://doi.org/10.1038/srep20378
Non-invasive Chamber-Specific Identification of Cardiomyocytes in Differentiating Pluripotent Stem Cells Brauchle E, Knopf A, Bauer H, Shen N, Linder S, Monaghan MG, Ellwanger K, Layland SL, Brucker SY, Nsair A, Schenke-Layland K. Stem Cell Reports. 2016 Feb 9;6(2):188-99. https://doi.org/10.1016/j.stemcr.2015.12.007
PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming Armbruster NS, Richardson JR, Schreiner J, Klenk J, Günter M, Kretschmer D, Pöschel S, Schenke-Layland K, Kalbacher H, Clark K, Autenrieth SE. J Immunol. 2016 Feb 1;196(3):1284-92. https://doi.org/10.4049/jimmunol.1502232
Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development Monaghan MG, Linneweh M, Liebscher S, Van Handel B, Layland SL, Schenke-Layland K. Development. 2016 Feb 1;143(3):473-82. https://doi.org/10.1242/dev.133843
ECM and ECM-like materials - Biomaterials for applications in regenerative medicine and cancer therapy Hinderer S, Layland SL, Schenke-Layland K. Adv Drug Deliv Rev. 2016 Feb 1;97:260-9. https://doi.org/10.1016/j.addr.2015.11.019
Modulation of inflammation and angiogenesis and changes in ECM GAG-activity via dual delivery of nucleic acids Browne S, Monaghan MG, Brauchle E, Berrio DC, Chantepie S, Papy-Garcia D, Schenke-Layland K, Pandit A. Biomaterials. 2015 Nov;69:133-47. https://doi.org/10.1016/j.biomaterials.2015.08.012
Prospects for regenerative medicine approaches in women's health Schenke-Layland K, Brucker SY. J Anat. 2015 Dec;227(6):781-5. https://doi.org/10.1111/joa.12336
Optical reprogramming and optical characterization of cells using femtosecond lasers Uchugonova A, Breunig HG, Augspurger C, Monaghan M, Schenke-Layland K, König K. In: König K, Ostendorf A, editors. Optically Induced Nanostructures: Biomedical and Technical Applications. Berlin: De Gruyter; 2015 Jun 23. Chapter 1. https://doi.org/None
Fluorescent Ly6G antibodies determine macrophage phagocytosis of neutrophils and alter the retrieval of neutrophils in mice Bucher K, Schmitt F, Autenrieth SE, Dillmann I, Nürnberg B, Schenke-Layland K, Beer-Hammer S. J Leukoc Biol. 2015 Sep;98(3):365-72. https://doi.org/10.1189/jlb.1AB1014-488RR
In vitro elastogenesis: instructing human vascular smooth muscle cells to generate an elastic fiber-containing extracellular matrix scaffold Hinderer S, Shena N, Ringuette LJ, Hansmann J, Reinhardt DP, Brucker SY, Davis EC, Schenke-Layland K. Biomed Mater. 2015 Mar 18;10(3):034102. https://doi.org/10.1088/1748-6041/10/3/034102
Generation and Assessment of Functional Biomaterial Scaffolds for Applications in Cardiovascular Tissue Engineering and Regenerative Medicine Hinderer S, Brauchle E, Schenke-Layland K. Adv Healthc Mater. 2015 Nov 18;4(16):2326-41. https://doi.org/10.1002/adhm.201400762
Human eye development is characterized by coordinated expression of fibrillin isoforms Hubmacher D, Reinhardt DP, Plesec T, Schenke-Layland K, Apte SS. Invest Ophthalmol Vis Sci. 2014 Nov 18;55(12):7934-44. https://doi.org/10.1167/iovs.14-15453
Drug and cell delivery for cardiac regeneration Hastings CL, Roche ET, Ruiz-Hernandez E, Schenke-Layland K, Walsh CJ, Duffy GP. Adv Drug Deliv Rev. 2015 Apr;84:85-106. https://doi.org/10.1016/j.addr.2014.08.006
Raman spectroscopy as an analytical tool for melanoma research Brauchle E, Noor S, Holtorf E, Garbe C, Schenke-Layland K, Busch C. Clin Exp Dermatol. 2014 Jul;39(5):636-45. https://doi.org/10.1111/ced.12357
Preserved bioactivity and tunable release of a SDF1-GPVI bi-specific protein using photo-crosslinked PEGda hydrogels Schesny MK, Monaghan M, Bindermann AH, Freund D, Seifert M, Eble JA, Vogel S, Gawaz MP, Hinderer S, Schenke-Layland K. Biomaterials. 2014 Aug;35(25):7180-7. https://doi.org/10.1016/j.biomaterials.2014.04.116
Cell death stages in single apoptotic and necrotic cells monitored by Raman microspectroscopy Brauchle E, Thude S, Brucker SY, Schenke-Layland K. Sci Rep. 2014 Apr 15;4:4698. https://doi.org/10.1038/srep04698
A collagen-based scaffold delivering exogenous microrna-29B to modulate extracellular matrix remodeling Monaghan M, Browne S, Schenke-Layland K, Pandit A. Mol Ther. 2014 Apr;22(4):786-96. https://doi.org/10.1038/mt.2013.288
Engineering of a bio-functionalized hybrid off-the-shelf heart valve Hinderer S, Seifert J, Votteler M, Shen N, Rheinlaender J, Schäffer TE, Schenke-Layland K. Biomaterials. 2014 Feb;35(7):2130-9. https://doi.org/10.1016/j.biomaterials.2013.10.080
A human in vitro model that mimics the renal proximal tubule Hoppensack A, Kazanecki CC, Colter D, Gosiewska A, Schanz J, Walles H, Schenke-Layland K. Tissue Eng Part C Methods. 2014 Jul;20(7):599-609. https://doi.org/10.1089/ten.TEC.2013.0446
Design and analysis of a squamous cell carcinoma in vitro model system Brauchle E, Johannsen H, Nolan S, Thude S, Schenke-Layland K. Biomaterials. 2013 Oct;34(30):7401-7. https://doi.org/10.1016/j.biomaterials.2013.06.016
Elastogenesis at the onset of human cardiac valve development Votteler M, Berrio DA, Horke A, Sabatier L, Reinhardt DP, Nsair A, Aikawa E, Schenke-Layland K. Development. 2013 Jun;140(11):2345-53. https://doi.org/10.1242/dev.093500
Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha Sdek P, Oyama K, Angelis E, Chan SS, Schenke-Layland K, MacLellan WR. PLoS One. 2013;8(3):e58319. https://doi.org/10.1371/journal.pone.0058319
Strategies in tissue engineering and regenerative medicine Schenke-Layland K, Walles H. Biotechnol J. 2013 Mar;8(3):278-9. https://doi.org/10.1002/biot.201300043
Tracheal tissue engineering: building on a strong foundation Hinderer S, Schenke-Layland K. Expert Rev Med Devices. 2013 Jan;10(1):33-5. https://doi.org/10.1586/erd.12.74
Raman spectroscopy in biomedicine - non-invasive in vitro analysis of cells and extracellular matrix components in tissues Brauchle E, Schenke-Layland K. Biotechnol J. 2013 Mar;8(3):288-97. https://doi.org/10.1002/biot.201200163
RNA isolation from fetal and adult human tissues for transcriptional profiling Votteler M, Layland SL, Lill G, Brockbank KG, Horke A, Schenke-Layland K. Biotechnol J. 2013 Mar;8(3):338-44. https://doi.org/10.1002/biot.201200164
Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. PLoS One. 2012;7(10):e45603. https://doi.org/10.1371/journal.pone.0045603
Non-contact, label-free monitoring of cells and extracellular matrix using Raman spectroscopy Votteler M, Carvajal Berrio DA, Pudlas M, Walles H, Schenke-Layland K. J Vis Exp. 2012 May 29;(63):3977. https://doi.org/10.3791/3977
Non-invasive identification of proteoglycans and chondrocyte differentiation state by Raman microspectroscopy Pudlas M, Brauchle E, Klein TJ, Hutmacher DW, Schenke-Layland K. J Biophotonics. 2013 Feb;6(2):205-11. https://doi.org/10.1002/jbio.201200064
Words of wisdom: Re: Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder Vaegler M, Schenke-Layland K, Stenzl A. Eur Urol. 2012 Jun;61(6):1263-4. https://doi.org/10.1016/j.eururo.2012.03.025
Engineering of fibrillar decorin matrices for a tissue-engineered trachea Hinderer S, Schesny M, Bayrak A, Ibold B, Hampel M, Walles T, Stock UA, Seifert M, Schenke-Layland K. Biomaterials. 2012 Jul;33(21):5259-66. https://doi.org/10.1016/j.biomaterials.2012.03.075
Oligonucleotide and Parylene Surface Coating of Polystyrene and ePTFE for Improved Endothelial Cell Attachment and Hemocompatibility Schleicher M, Hansmann J, Elkin B, Kluger PJ, Liebscher S, Huber AJ, Fritze O, Schille C, Müller M, Schenke-Layland K, Seifert M, Walles H, Wendel HP, Stock UA. Int J Biomater. 2012;2012:397813. https://doi.org/10.1155/2012/397813
Preclinical evaluation of ice-free cryopreserved arteries: structural integrity and hemocompatibility Huber AJ, Brockbank KG, Riemann I, Schleicher M, Schenke-Layland K, Fritze O, Wendel HP, Stock UA. Cells Tissues Organs. 2012;196(3):262-70. https://doi.org/10.1159/000334544
Ice-free cryopreservation of heart valve allografts: better extracellular matrix preservation in vivo and preclinical results Brockbank KG, Schenke-Layland K, Greene ED, Chen Z, Fritze O, Schleicher M, Kaulitz R, Riemann I, Fend F, Albes JM, Stock UA, Lisy M. Cell Tissue Bank. 2012 Dec;13(4):663-71. https://doi.org/10.1007/s10561-011-9288-7
Age-related changes in the elastic tissue of the human aorta Fritze O, Romero B, Schleicher M, Jacob MP, Oh DY, Starcher B, Schenke-Layland K, Bujan J, Stock UA. J Vasc Res. 2012;49(1):77-86. https://doi.org/10.1159/000331278
Skin tissue engineering--in vivo and in vitro applications Groeber F, Holeiter M, Hampel M, Hinderer S, Schenke-Layland K. Clin Plast Surg. 2012 Jan;39(1):33-58. https://doi.org/10.1016/j.cps.2011.09.007
Raman spectroscopy for the non-contact and non-destructive monitoring of collagen damage within tissues Votteler M, Carvajal Berrio DA, Pudlas M, Walles H, Stock UA, Schenke-Layland K. J Biophotonics. 2012 Jan;5(1):47-56. https://doi.org/10.1002/jbio.201100068
Raman spectroscopy: a noninvasive analysis tool for the discrimination of human skin cells Pudlas M, Koch S, Bolwien C, Thude S, Jenne N, Hirth T, Walles H, Schenke-Layland K. Tissue Eng Part C Methods. 2011 Oct;17(10):1027-40. https://doi.org/10.1089/ten.tec.2011.0082
The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine Pusch J, Votteler M, Göhler S, Engl J, Hampel M, Walles H, Schenke-Layland K. Biomaterials. 2011 Oct;32(30):7469-78. https://doi.org/10.1016/j.biomaterials.2011.06.035
In vitro human tissue models--moving towards personalized regenerative medicine Schenke-Layland K, Nerem RM. Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):195-6. https://doi.org/10.1016/j.addr.2011.05.001
Allogeneic heart valve storage above the glass transition at -80°C Brockbank KG, Wright GJ, Yao H, Greene ED, Chen ZZ, Schenke-Layland K. Ann Thorac Surg. 2011 Jun;91(6):1829-35. https://doi.org/10.1016/j.athoracsur.2011.02.043
From tissue engineering to regenerative medicine--the potential and the pitfalls Schenke-Layland K. Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):193-4. https://doi.org/10.1016/j.addr.2011.04.003
Recapitulation of the embryonic cardiovascular progenitor cell niche Schenke-Layland K, Nsair A, Van Handel B, Angelis E, Gluck JM, Votteler M, Goldhaber JI, Mikkola HK, Kahn M, Maclellan WR. Biomaterials. 2011 Apr;32(11):2748-56. https://doi.org/10.1016/j.biomaterials.2010.12.046
Skin tissue engineering--in vivo and in vitro applications Groeber F, Holeiter M, Hampel M, Hinderer S, Schenke-Layland K. Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):352-66. https://doi.org/10.1016/j.addr.2011.01.005
Guidance for removal of fetal bovine serum from cryopreserved heart valve processing Brockbank KG, Heacox AE, Schenke-Layland K. Cells Tissues Organs. 2011;193(4):264-73. https://doi.org/10.1159/000321166
Stem cell microenvironments--unveiling the secret of how stem cell fate is defined Votteler M, Kluger PJ, Walles H, Schenke-Layland K. Macromol Biosci. 2010 Nov 10;10(11):1302-15. https://doi.org/10.1002/mabi.201000102
Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13742-7. https://doi.org/10.1073/pnas.1002077107
Electrospun poly(D/L-lactide-co-L-lactide) hybrid matrix: a novel scaffold material for soft tissue engineering Kluger PJ, Wyrwa R, Weisser J, Maierle J, Votteler M, Rode C, Schnabelrauch M, Walles H, Schenke-Layland K. J Mater Sci Mater Med. 2010 Sep;21(9):2665-71. https://doi.org/10.1007/s10856-010-4128-z
Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse Li X, Wu K, Edman M, Schenke-Layland K, MacVeigh-Aloni M, Janga SR, Schulz B, Hamm-Alvarez SF. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5019-29. https://doi.org/10.1167/iovs.09-4523
The performance of ice-free cryopreserved heart valve allografts in an orthotopic pulmonary sheep model Lisy M, Pennecke J, Brockbank KG, Fritze O, Schleicher M, Schenke-Layland K, Kaulitz R, Riemann I, Weber CN, Braun J, Mueller KE, Fend F, Scheunert T, Gruber AD, Albes JM, Huber AJ, Stock UA. Biomaterials. 2010 Jul;31(20):5306-11. https://doi.org/10.1016/j.biomaterials.2010.03.038
Simplified pulse reactor for real-time long-term in vitro testing of biological heart valves Schleicher M, Sammler G, Schmauder M, Fritze O, Huber AJ, Schenke-Layland K, Ditze G, Stock UA. Ann Biomed Eng. 2010 May;38(5):1919-27. https://doi.org/10.1007/s10439-010-9975-8
Impact of heart valve decellularization on 3-D ultrastructure, immunogenicity and thrombogenicity Zhou J, Fritze O, Schleicher M, Wendel HP, Schenke-Layland K, Harasztosi C, Hu S, Stock UA. Biomaterials. 2010 Mar;31(9):2549-54. https://doi.org/10.1016/j.biomaterials.2009.11.088
Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy Schenke-Layland K, Xie J, Magnusson M, Angelis E, Li X, Wu K, Reinhardt DP, Maclellan WR, Hamm-Alvarez SF. Exp Eye Res. 2010 Feb;90(2):223-37. https://doi.org/10.1016/j.exer.2009.10.008
Facilitated noninvasive visualization of collagen and elastin in blood vessels Fritze O, Schleicher M, König K, Schenke-Layland K, Stock U, Harasztosi C. Tissue Eng Part C Methods. 2010 Aug;16(4):705-10. https://doi.org/10.1089/ten.TEC.2009.0309
Cardiomyopathy is associated with structural remodelling of heart valve extracellular matrix Schenke-Layland K, Stock UA, Nsair A, Xie J, Angelis E, Fonseca CG, Larbig R, Mahajan A, Shivkumar K, Fishbein MC, MacLellan WR. Eur Heart J. 2009 Sep;30(18):2254-65. https://doi.org/10.1093/eurheartj/ehp267
The use of three-dimensional nanostructures to instruct cells to produce extracellular matrix for regenerative medicine strategies Schenke-Layland K, Rofail F, Heydarkhan S, Gluck JM, Ingle NP, Angelis E, Choi CH, MacLellan WR, Beygui RE, Shemin RJ, Heydarkhan-Hagvall S. Biomaterials. 2009 Sep;30(27):4665-75. https://doi.org/10.1016/j.biomaterials.2009.05.033
Non-invasive multiphoton imaging of extracellular matrix structures Schenke-Layland K. J Biophotonics. 2008 Dec;1(6):451-62. https://doi.org/10.1002/jbio.200810045
Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wang XC, Maclellan WR, Crooks GM. Stem Cells Dev. 2009 Jul-Aug;18(6):919-28. https://doi.org/10.1089/scd.2008.0293
Adipose tissue-derived cells improve cardiac function following myocardial infarction Schenke-Layland K, Strem BM, Jordan MC, Deemedio MT, Hedrick MH, Roos KP, Fraser JK, Maclellan WR. J Surg Res. 2009 May 15;153(2):217-23. https://doi.org/10.1016/j.jss.2008.03.019
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages Schenke-Layland K, Rhodes KE, Angelis E, Butylkova Y, Heydarkhan-Hagvall S, Gekas C, Zhang R, Goldhaber JI, Mikkola HK, Plath K, MacLellan WR. Stem Cells. 2008 Jun;26(6):1537-46. https://doi.org/10.1634/stemcells.2008-0033
Quantitative second harmonic generation imaging of cartilage damage Brockbank KG, MacLellan WR, Xie J, Hamm-Alvarez SF, Chen ZZ, Schenke-Layland K. Cell Tissue Bank. 2008 Dec;9(4):299-307. https://doi.org/10.1007/s10561-008-9070-7
A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium Angelis E, Garcia A, Chan SS, Schenke-Layland K, Ren S, Goodfellow SJ, Jordan MC, Roos KP, White RJ, MacLellan WR. Circ Res. 2008 May 23;102(10):1222-9. https://doi.org/10.1161/CIRCRESAHA.107.163550
Human adipose stem cells: a potential cell source for cardiovascular tissue engineering Heydarkhan-Hagvall S, Schenke-Layland K, Yang JQ, Heydarkhan S, Xu Y, Zuk PA, MacLellan WR, Beygui RE. Cells Tissues Organs. 2008;187(4):263-74. https://doi.org/10.1159/000113407
Influence of systematically varied nano-scale topography on cell morphology and adhesion Heydarkhan-Hagvall S, Choi CH, Dunn J, Heydarkhan S, Schenke-Layland K, MacLellan WR, Beygui RE. Cell Commun Adhes. 2007 Sep-Oct;14(5):181-94. https://doi.org/10.1080/15419060701755594
The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury Anderson CD, Heydarkhan-Hagvall S, Schenke-Layland K, Yang JQ, Jordan MC, Kim JK, Brown DA, Zuk PA, Laks H, Roos KP, Maclellan WR, Beygui RE. J Surg Res. 2008 Aug;148(2):164-71. https://doi.org/10.1016/j.jss.2007.08.005
Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome Schenke-Layland K, Xie J, Angelis E, Starcher B, Wu K, Riemann I, MacLellan WR, Hamm-Alvarez SF. Matrix Biol. 2008 Jan;27(1):53-66. https://doi.org/10.1016/j.matbio.2007.07.005
Phenotypical plasticity of vascular smooth muscle cells-effect of in vitro and in vivo shear stress for tissue engineering of blood vessels Opitz F, Schenke-Layland K, Cohnert TU, Stock UA. Tissue Eng. 2007 Oct;13(10):2505-14. https://doi.org/10.1089/ten.2006.0424
Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability Schenke-Layland K, Xie J, Heydarkhan-Hagvall S, Hamm-Alvarez SF, Stock UA, Brockbank KG, MacLellan WR. Ann Thorac Surg. 2007 May;83(5):1641-50. https://doi.org/10.1016/j.athoracsur.2006.12.005
Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells Schenke-Layland K, Angelis E, Rhodes KE, Heydarkhan-Hagvall S, Mikkola HK, Maclellan WR. Stem Cells. 2007 Jun;25(6):1529-38. https://doi.org/10.1634/stemcells.2006-0729
Two-photon microscopes and in vivo multiphoton tomographs--powerful diagnostic tools for tissue engineering and drug delivery Schenke-Layland K, Riemann I, Damour O, Stock UA, König K. Adv Drug Deliv Rev. 2006 Sep 15;58(7):878-96. https://doi.org/10.1016/j.addr.2006.07.004
Prevention of device-related tissue damage during percutaneous deployment of tissue-engineered heart valves Stock UA, Degenkolbe I, Attmann T, Schenke-Layland K, Freitag S, Lutter G. J Thorac Cardiovasc Surg. 2006 Jun;131(6):1323-30. https://doi.org/10.1016/j.jtcvs.2006.01.053
Impact of cryopreservation on extracellular matrix structures of heart valve leaflets Schenke-Layland K, Madershahian N, Riemann I, Starcher B, Halbhuber KJ, König K, Stock UA. Ann Thorac Surg. 2006 Mar;81(3):918-26. https://doi.org/10.1016/j.athoracsur.2005.09.016
Imaging of cardiovascular structures using near-infrared femtosecond multiphoton laser scanning microscopy Schenke-Layland K, Riemann I, Stock UA, König K. J Biomed Opt. 2005 Mar-Apr;10(2):024017. https://doi.org/10.1117/1.1896966
Tissue engineering of aortic tissue: dire consequence of suboptimal elastic fiber synthesis in vivo Opitz F, Schenke-Layland K, Cohnert TU, Starcher B, Halbhuber KJ, Martin DP, Stock UA. Cardiovasc Res. 2004 Sep 1;63(4):719-30. https://doi.org/10.1016/j.cardiores.2004.05.002
Multiphoton autofluorescence imaging of intratissue elastic fibers König K, Schenke-Layland K, Riemann I, Stock UA. Biomaterials. 2005 Feb;26(5):495-500. https://doi.org/10.1016/j.biomaterials.2004.02.059
Comparative study of cellular and extracellular matrix composition of native and tissue engineered heart valves Schenke-Layland K, Riemann I, Opitz F, König K, Halbhuber KJ, Stock UA. Matrix Biol. 2004 May;23(2):113-25. https://doi.org/10.1016/j.matbio.2004.03.005
ProteinChip system technology: a powerful tool to analyze expression differences in tissue-engineered blood vessels Opitz F, Melle C, Schenke-Layland K, Degenkolbe I, Martin DP, Von Eggeling F, Wahlers T, Stock UA. Tissue Eng. 2004 Mar-Apr;10(3-4):611-20. https://doi.org/10.1089/107632704323061960
Tissue engineering of ovine aortic blood vessel substitutes using applied shear stress and enzymatically derived vascular smooth muscle cells Opitz F, Schenke-Layland K, Richter W, Martin DP, Degenkolbe I, Wahlers T, Stock UA. Ann Biomed Eng. 2004 Feb;32(2):212-22. https://doi.org/10.1023/b:abme.0000012741.85600.f1
Complete dynamic repopulation of decellularized heart valves by application of defined physical signals-an in vitro study Schenke-Layland K, Opitz F, Gross M, Döring C, Halbhuber KJ, Schirrmeister F, Wahlers T, Stock UA. Cardiovasc Res. 2003 Dec 1;60(3):497-509. https://doi.org/10.1016/j.cardiores.2003.09.002
Impact of decellularization of xenogeneic tissue on extracellular matrix integrity for tissue engineering of heart valves Schenke-Layland K, Vasilevski O, Opitz F, König K, Riemann I, Halbhuber KJ, Wahlers T, Stock UA. J Struct Biol. 2003 Sep;143(3):201-8. https://doi.org/10.1016/j.jsb.2003.08.002
cAMP-induced Interleukin-10 promoter activation depends on CCAAT/enhancer-binding protein expression and monocytic differentiation Brenner S, Prösch S, Schenke-Layland K, Riese U, Gausmann U, Platzer C. J Biol Chem. 2003 Feb 21;278(8):5597-604. https://doi.org/10.1074/jbc.M207448200