Myocardial infarction (MI) results in debilitating remodeling of the myocardial extracellular matrix (ECM). In a proof-of-principle study, it was sought to modulate the aggressive remodeling by injecting a hyaluronic acid-based reservoir delivering exogenous microRNA-29B (miR-29B).

Recombinant Proteins

Our group has identified target ECM proteins for cardiovascular regenerative therapies and tissue-engineered transplants. These essential proteins, created by transfected CHO cells, are now produced in our lab and are being prepared for in vivo studies.