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Publication List

  1. Mapping human haematopoietic stem cells from haemogenic endothelium to birth
    Calvanese V, Capellera-Garcia S, Ma F, Fares I, Liebscher S, Ng ES, Ekstrand S, Aguadé-Gorgorió J, Vavilina A, Lefaudeux D, Nadel B, Li JY, Wang Y, Lee LK, Ardehali R, Iruela-Arispe ML, Pellegrini M, Stanley EG, Elefanty AG, Schenke-Layland K, Mikkola HKA.
    Nature. 2022 Apr;604(7906):534-540.
    https://doi.org/10.1038/s41586-022-04571-x
  2. Raman Microspectroscopy Identifies Biochemical Activation Fingerprints in THP-1- and PBMC-Derived Macrophages
    Feuerer N, Carvajal Berrio DA, Billing F, Segan S, Weiss M, Rothbauer U, Marzi J, Schenke-Layland K.
    Biomedicines. 2022 Apr 25;10(5):989.
    https://doi.org/10.3390/biomedicines10050989
  3. Marker-Independent Monitoring of in vitro and in vivo Degradation of Supramolecular Polymers Applied in Cardiovascular in situ Tissue Engineering
    Marzi J, Munnig Schmidt EC, Brauchle EM, Wissing TB, Bauer H, Serrero A, Söntjens SHM, Bosman AW, Cox MAJ, Smits AIPM, Schenke-Layland K.
    Front Cardiovasc Med. 2022 May 17;9:885873.
    https://doi.org/10.3389/fcvm.2022.885873
  4. Data-Driven Identification of Biomarkers for In Situ Monitoring of Drug Treatment in Bladder Cancer Organoids
    Becker L, Fischer F, Fleck JL, Harland N, Herkommer A, Stenzl A, Aicher WK, Schenke-Layland K, Marzi J.
    Int J Mol Sci. 2022 Jun 23;23(13):6956.
    https://doi.org/10.3390/ijms23136956
  5. Type 1 diabetes and engineering enhanced islet transplantation
    Jeyagaran A, Lu CE, Zbinden A, Birkenfeld AL, Brucker SY, Layland SL.
    Adv Drug Deliv Rev. 2022 Oct;189:114481.
    https://doi.org/10.1016/j.addr.2022.114481
  6. Organ-specific endothelial cell heterogenicity and its impact on regenerative medicine and biomedical engineering applications
    Urbanczyk M, Zbinden A, Schenke-Layland K.
    Adv Drug Deliv Rev. 2022 Jul;186:114323.
    https://doi.org/10.1016/j.addr.2022.114323
  7. Autologous Human Immunocompetent White Adipose Tissue-on-Chip
    Rogal J, Roosz J, Teufel C, Cipriano M, Xu R, Eisler W, Weiss M, Schenke-Layland K, Loskill P.
    Adv Sci (Weinh). 2022 Jun;9(18):e2104451.
    https://doi.org/10.1002/advs.202104451
  8. Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia
    Marzi J, Stope MB, Henes M, Koch A, Wenzel T, Holl M, Layland SL, Neis F, Bösmüller H, Ruoff F, Templin M, Krämer B, Staebler A, Barz J, Carvajal Berrio DA, Enderle M, Loskill PM, Brucker SY, Schenke-Layland K, Weiss M.
    Cancers (Basel). 2022 Apr 12;14(8):1933.
    https://doi.org/10.3390/cancers14081933
  9. Cell Type-Specific Anti-Adhesion Properties of Peritoneal Cell Treatment with Plasma-Activated Media (PAM)
    Holl M, Rasch ML, Becker L, Keller AL, Schultze-Rhonhof L, Ruoff F, Templin M, Keller S, Neis F, Keßler F, Andress J, Bachmann C, Krämer B, Schenke-Layland K, Brucker SY, Marzi J, Weiss M.
    Biomedicines. 2022 Apr 18;10(4):927.
    https://doi.org/10.3390/biomedicines10040927
  10. Lipidome profiling with Raman microspectroscopy identifies macrophage response to surface topographies of implant materials
    Feuerer N, Marzi J, Brauchle EM, Carvajal Berrio DA, Billing F, Weiss M, Jakobi M, Schneiderhan-Marra N, Shipp C, Schenke-Layland K.
    Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2113694118.
    https://doi.org/10.1073/pnas.2113694118
  11. Development of a bi-layered cryogenic electrospun polylactic acid scaffold to study calcific aortic valve disease in a 3D co-culture model
    Stadelmann K, Weghofer A, Urbanczyk M, Maulana TI, Loskill P, Jones PD, Schenke-Layland K.
    Acta Biomater. 2022 Mar 1;140:364-378.
    https://doi.org/10.1016/j.actbio.2021.11.030
  12. Raman Imaging and Fluorescence Lifetime Imaging Microscopy for Diagnosis of Cancer State and Metabolic Monitoring
    Becker L, Janssen N, Layland SL, Mürdter TE, Nies AT, Schenke-Layland K, Marzi J.
    Cancers (Basel). 2021 Nov 13;13(22):5682.
    https://doi.org/10.3390/cancers13225682
  13. Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model
    Armento A, Murali A, Marzi J, Almansa-Garcia AC, Arango-Gonzalez B, Kilger E, Clark SJ, Schenke-Layland K, Ramlogan-Steel CA, Steel JC, Ueffing M.
    Biomolecules. 2021 Nov 3;11(11):1621.
    https://doi.org/10.3390/biom11111621
  14. Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
    Petrigliano FA, Liu NQ, Lee S, Tassey J, Sarkar A, Lin Y, Li L, Yu Y, Geng D, Zhang J, Shkhyan R, Bogdanov J, Van Handel B, Ferguson GB, Lee Y, Hinderer S, Tseng KC, Kavanaugh A, Crump JG, Pyle AD, Schenke-Layland K, Billi F, Wang L, Lieberman J, Hurtig M, Evseenko D.
    NPJ Regen Med. 2021 Nov 23;6(1):77.
    https://doi.org/10.1038/s41536-021-00187-3
  15. Three Water Restriction Schedules Used in Rodent Behavioral Tasks Transiently Impair Growth and Differentially Evoke a Stress Hormone Response without Causing Dehydration
    Vasilev D, Havel D, Liebscher S, Slesiona-Kuenzel S, Logothetis NK, Schenke-Layland K, Totah NK.
    eNeuro. 2021 Dec 14;8(6):ENEURO.0424-21.2021.
    https://doi.org/10.1523/ENEURO.0424-21.2021
  16. Hyaluronic Acid-Functionalized Hybrid Gelatin-Poly-L-Lactide Scaffolds with Tunable Hydrophilicity
    Piccirillo G, Feuerer N, Carvajal Berrio DA, Layland SL, Reimer Hinderer S, Bochicchio B, Schenke-Layland K.
    Tissue Eng Part C Methods. 2021 Nov;27(11):589-604.
    https://doi.org/10.1089/ten.TEC.2021.0178
  17. Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation
    Brandhorst D, Brandhorst H, Lee Layland S, Acreman S, Schenke-Layland K, Johnson PRV.
    Acta Biomater. 2022 Jan 1;137:92-102.
    https://doi.org/10.1016/j.actbio.2021.10.013
  18. Imaging of α-Synuclein Aggregates in a Rat Model of Parkinson's Disease Using Raman Microspectroscopy
    Sevgi F, Brauchle EM, Carvajal Berrio DA, Schenke-Layland K, Casadei N, Salker MS, Riess O, Singh Y.
    Front Cell Dev Biol. 2021 Sep 10;9:664365.
    https://doi.org/10.3389/fcell.2021.664365
  19. The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model
    Beatty R, Lu CE, Marzi J, Levey RE, Carvajal Berrio D, Lattanzi G, Wylie R, O'Connor R, Wallace E, Ghersi G, Salamone M, Dolan EB, Layland SL, Schenke-Layland K, Duffy GP.
    Tissue Eng Part C Methods. 2021 Oct;27(10):515-528.
    https://doi.org/10.1089/ten.TEC.2021.0163
  20. Distinct Effects of Heparin and Interleukin-4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats
    Bonito V, Koch SE, Krebber MM, Carvajal-Berrio DA, Marzi J, Duijvelshoff R, Lurier EB, Buscone S, Dekker S, de Jong SMJ, Mes T, Vaessen KRD, Brauchle EM, Bosman AW, Schenke-Layland K, Verhaar MC, Dankers PYW, Smits AIPM, Bouten CVC.
    Adv Healthc Mater. 2021 Nov;10(21):e2101103.
    https://doi.org/10.1002/adhm.202101103
  21. Inflammatory and regenerative processes in bioresorbable synthetic pulmonary valves up to two years in sheep-Spatiotemporal insights augmented by Raman microspectroscopy
    De Kort BJ, Marzi J, Brauchle EM, Lichauco AM, Bauer HS, Serrero A, Dekker S, Cox MAJ, Schoen FJ, Schenke-Layland K, Bouten CVC, Smits AIPM.
    Acta Biomater. 2021 Nov;135:243-259.
    https://doi.org/10.1016/j.actbio.2021.09.005
  22. Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone
    Jiménez-Altayó F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke-Layland K, Jiménez-Xarrié E, Planas AM.
    J Cereb Blood Flow Metab. 2022 Jan;42(1):162-174.
    https://doi.org/10.1177/0271678X211033362
  23. Organoids for the advancement of intraoperative diagnostic procedures
    Harland N, Amend B, Lipke N, Brucker SY, Fend F, Herkommer A, Lensch H, Sawodny O, Schäffer TE, Schenke-Layland K, Tarín Sauer C, Aicher W, Stenzl A.
    Urologe A. 2021 Sep;60(9):1159-1166.
    https://doi.org/10.1007/s00120-021-01595-5
  24. Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms
    Sugiyama K, Marzi J, Alber J, Brauchle EM, Ando M, Yamashiro Y, Ramkhelawon B, Schenke-Layland K, Yanagisawa H.
    Cell Rep Med. 2021 Apr 28;2(5):100261.
    https://doi.org/10.1016/j.xcrm.2021.100261
  25. Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration
    Zbinden A, Layland SL, Urbanczyk M, Carvajal Berrio DA, Marzi J, Zauner M, Hammerschmidt A, Brauchle EM, Sudrow K, Fink S, Templin M, Liebscher S, Klein G, Deb A, Duffy GP, Crooks GM, Eble JA, Mikkola HKA, Nsair A, Seifert M, Schenke-Layland K.
    Adv Sci (Weinh). 2020 Dec 21;8(4):2002500.
    https://doi.org/10.1002/advs.202002500
  26. Integration of Electrospun Membranes into Low-Absorption Thermoplastic Organ-on-Chip
    Chuchuy J, Rogal J, Ngo T, Stadelmann K, Antkowiak L, Achberger K, Liebau S, Schenke-Layland K, Loskill P.
    ACS Biomater Sci Eng. 2021 Jul 12;7(7):3006-3017.
    https://doi.org/10.1021/acsbiomaterials.0c01062
  27. Laparoscopic Peritoneal Wash Cytology-Derived Primary Human Mesothelial Cells for In Vitro Cell Culture and Simulation of Human Peritoneum
    Holl M, Becker L, Keller AL, Feuerer N, Marzi J, Carvajal Berrio DA, Jakubowski P, Neis F, Pauluschke-Fröhlich J, Brucker SY, Schenke-Layland K, Krämer B, Weiss M.
    Biomedicines. 2021 Feb 10;9(2):176.
    https://doi.org/10.3390/biomedicines9020176
  28. Human heart-forming organoids recapitulate early heart and foregut development
    Drakhlis L, Biswanath S, Farr CM, Lupanow V, Teske J, Ritzenhoff K, Franke A, Manstein F, Bolesani E, Kempf H, Liebscher S, Schenke-Layland K, Hegermann J, Nolte L, Meyer H, de la Roche J, Thiemann S, Wahl-Schott C, Martin U, Zweigerdt R.
    Nat Biotechnol. 2021 Jun;39(6):737-746.
    https://doi.org/10.1038/s41587-021-00815-9
  29. Elastin-like hydrogel stimulates angiogenesis in a severe model of critical limb ischemia (CLI): An insight into the glyco-host response
    Marsico G, Jin C, Abbah SA, Brauchle EM, Thomas D, Rebelo AL, Orbanić D, Chantepie S, Contessotto P, Papy-Garcia D, Rodriguez-Cabello C, Kilcoyne M, Schenke-Layland K, Karlsson NG, McCullagh KJA, Pandit A.
    Biomaterials. 2021 Feb;269:120641.
    https://doi.org/10.1016/j.biomaterials.2020.120641
  30. Fibronectin adsorption on oxygen plasma-treated polyurethane surfaces modulates endothelial cell response
    Daum R, Mrsic I, Hutterer J, Junginger A, Hinderer S, Meixner AJ, Gauglitz G, Chassé T, Schenke-Layland K.
    J Mater Chem B. 2021 Feb 14;9(6):1647-1660.
    https://doi.org/10.1039/d0tb02757j
  31. Macrophage retrival from 3D biomaterials: A detailed comparison of common dissociation methods
    Feuerer N, Morschl J, Daum R, Weiss M, Hinderer S, Schenke-Layland K, Shipp C.
    J Immunol Regen Med 2021 in press.
    https://doi.org/10.1016/j.regen.2020.100035
  32. Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation
    Chitiashvili T, Dror I, Kim R, Hsu FM, Chaudhari R, Pandolfi E, Chen D, Liebscher S, Schenke-Layland K, Plath K, Clark A.
    Nat Cell Biol. 2020 Dec;22(12):1436-1446.
    https://doi.org/10.1038/s41556-020-00607-4
  33. Fluorescence lifetime metabolic mapping of hypoxia-induced damage in pancreatic pseudo-islets
    Zbinden A, Carvajal Berrio DA, Urbanczyk M, Layland SL, Bosch M, Fliri S, Lu CE, Jeyagaran A, Loskill P, Duffy GP, Schenke-Layland K.
    J Biophotonics. 2020 Dec;13(12):e202000375.
    https://doi.org/10.1002/jbio.202000375
  34. Collagen and Endothelial Cell Coculture Improves β-Cell Functionality and Rescues Pancreatic Extracellular Matrix
    Zbinden A, Urbanczyk M, Layland SL, Becker L, Marzi J, Bosch M, Loskill P, Duffy GP, Schenke-Layland K.
    Tissue Eng Part A. 2020 Nov 6.
    https://doi.org/10.1089/ten.TEA.2020.0250
  35. A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells
    Xi H, Langerman J, Sabri S, Chien P, Young CS, Younesi S, Hicks M, Gonzalez K, Fujiwara W, Marzi J, Liebscher S, Spencer M, Van Handel B, Evseenko D, Schenke-Layland K, Plath K, Pyle AD.
    Cell Stem Cell. 2020 Jul 2;27(1):181-185.
    https://doi.org/10.1016/j.stem.2020.06.006
  36. Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma
    Spenlé C, Loustau T, Murdamoothoo D, Erne W, Beghelli-de la Forest Divonne S, Veber R, Petti L, Bourdely P, Mörgelin M, Brauchle EM, Cremel G, Randrianarisoa V, Camara A, Rekima S, Schaub S, Nouhen K, Imhof T, Hansen U, Paul N, Carapito R, Pythoud N, Hirschler A, Carapito C, Dumortier H, Mueller CG, Koch M, Schenke-Layland K, Kon S, Sudaka A, Anjuère F, Van Obberghen-Schilling E, Orend G.
    Cancer Immunol Res. 2020 Sep;8(9):1122-1138.
    https://doi.org/10.1158/2326-6066.CIR-20-0074
  37. HepaChip-MP - a twenty-four chamber microplate for a continuously perfused liver coculture model
    Busche M, Tomilova O, Schütte J, Werner S, Beer M, Groll N, Hagmeyer B, Pawlak M, Jones PD, Schmees C, Becker H, Schnabel J, Gall K, Hemmler R, Matz-Soja M, Damm G, Beuck S, Klaassen T, Moer J, Ullrich A, Runge D, Schenke-Layland K, Gebhardt R, Stelzle M.
    Lab Chip. 2020 Aug 11;20(16):2911-2926.
    https://doi.org/10.1039/d0lc00357c
  38. WAT-on-a-chip integrating human mature white adipocytes for mechanistic research and pharmaceutical applications
    Rogal J, Binder C, Kromidas E, Roosz J, Probst C, Schneider S, Schenke-Layland K, Loskill P.
    Sci Rep. 2020 Apr 20;10(1):6666.
    https://doi.org/10.1038/s41598-020-63710-4
  39. Fibronectin Adsorption on Electrospun Synthetic Vascular Grafts Attracts Endothelial Progenitor Cells and Promotes Endothelialization in Dynamic In Vitro Culture
    Daum R, Visser D, Wild C, Kutuzova L, Schneider M, Lorenz G, Weiss M, Hinderer S, Stock UA, Seifert M, Schenke-Layland K.
    Cells. 2020 Mar 23;9(3):778.
    https://doi.org/10.3390/cells9030778
  40. Trans-Mucosal Efficacy of Non-Thermal Plasma Treatment on Cervical Cancer Tissue and Human Cervix Uteri by a Next Generation Electrosurgical Argon Plasma Device
    Wenzel T, Carvajal Berrio DA, Reisenauer C, Layland S, Koch A, Wallwiener D, Brucker SY, Schenke-Layland K, Brauchle EM, Weiss M.
    Cancers (Basel). 2020 Jan 22;12(2):267.
    https://doi.org/10.3390/cancers12020267
  41. The role of extracellular matrix in biomechanics and its impact on bioengineering of cells and 3D tissues
    Urbanczyk M, Layland SL, Schenke-Layland K.
    Matrix Biol. 2020 Jan;85-86:1-14.
    https://doi.org/10.1016/j.matbio.2019.11.005
  42. Towards automation in biologics production via Raman micro-spectroscopy, laser-induced forward cell transfer and surface-enhanced Raman spectroscopy
    Jaeckle E, Brauchle E, Nottrodt N, Wehner M, Lensing R, Gillner A, Schenke-Layland K, Bach M, Burger-Kentischer A.
    J Biotechnol. 2020 Nov 10;323:313-321.
    https://doi.org/10.1016/j.jbiotec.2020.09.001
  43. Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study
    Guo S, Beleites C, Neugebauer U, Abalde-Cela S, Afseth NK, Alsamad F, Anand S, Araujo-Andrade C, Aškrabić S, Avci E, Baia M, Baranska M, Baria E, Batista de Carvalho LAE, de Bettignies P, Bonifacio A, Bonnier F, Brauchle EM, Byrne HJ, Chourpa I, Cicchi R, Cuisinier F, Culha M, Dahms M, David C, Duponchel L, Duraipandian S, El-Mashtoly SF, Ellis DI, Eppe G, Falgayrac G, Gamulin O, Gardner B, Gardner P, Gerwert K, Giamarellos-Bourboulis EJ, Gizurarson S, Gnyba M, Goodacre R, Grysan P, Guntinas-Lichius O, Helgadottir H, Grošev VM, Kendall C, Kiselev R, Kölbach M, Krafft C, Krishnamoorthy S, Kubryck P, Lendl B, Loza-Alvarez P, Lyng FM, Machill S, Malherbe C, Marro M, Marques MPM, Matuszyk E, Morasso CF, Moreau M, Muhamadali H, Mussi V, Notingher I, Pacia MZ, Pavone FS, Penel G, Petersen D, Piot O, Rau JV, Richter M, Rybarczyk MK, Salehi H, Schenke-Layland K, Schlücker S, Schosserer M, Schütze K, Sergo V, Sinjab F, Smulko J, Sockalingum GD, Stiebing C, Stone N, Untereiner V, Vanna R, Wieland K, Popp J, Bocklitz T.
    Anal Chem. 2020 Dec 15;92(24):15745-15756.
    https://doi.org/10.1021/acs.analchem.0c02696
  44. Call for Review Papers: Tissue Engineering, Part B
    Schenke-Layland K, Shin H.
    Tissue Eng Part C Methods. 2020 Dec;26(12):597.
    https://doi.org/10.1089/ten.tec.2020.29009.cfp9
  45. Advanced drug delivery 2020 - Parts 1,2 and 3
    Ghandehari H, Chan HK, Harashima H, MacKay JA, Minko T, Schenke-Layland K, Shen Y, Vicent MJ.
    Adv Drug Deliv Rev. 2020;156:1-2.
    https://doi.org/10.1016/j.addr.2020.11.003
  46. Controlled Heterotypic Pseudo-Islet Assembly of Human β-Cells and Human Umbilical Vein Endothelial Cells Using Magnetic Levitation
    Urbanczyk M, Zbinden A, Layland SL, Duffy G, Schenke-Layland K.
    Tissue Eng Part A. 2020 Apr;26(7-8):387-399.
    https://doi.org/10.1089/ten.TEA.2019.0158
  47. Molecular Effects and Tissue Penetration Depth of Physical Plasma in Human Mucosa Analyzed by Contact- and Marker-Independent Raman Microspectroscopy
    Wenzel T, Carvajal Berrio DA, Daum R, Reisenauer C, Weltmann KD, Wallwiener D, Brucker SY, Schenke-Layland K, Brauchle EM, Weiss M.
    ACS Appl Mater Interfaces. 2019 Nov 20;11(46):42885-42895.
    https://doi.org/10.1021/acsami.9b13221
  48. Hyaluronic acid as a macromolecular crowding agent for production of cell-derived matrices
    Shendi D, Marzi J, Linthicum W, Rickards AJ, Dolivo DM, Keller S, Kauss MA, Wen Q, McDevitt TC, Dominko T, Schenke-Layland K, Rolle MW.
    Acta Biomater. 2019 Dec;100:292-305.
    https://doi.org/10.1016/j.actbio.2019.09.042
  49. Donor age significantly influences the Raman spectroscopic biomolecular fingerprint of human pancreatic extracellular matrix proteins following collagenase-based digestion
    Spiers RM, Marzi J, Brauchle EM, Cross SE, Vaughan RH, Bateman PA, Hughes SJ, Schenke-Layland K, Johnson PRV.
    Acta Biomater. 2019 Nov;99:269-283.
    https://doi.org/10.1016/j.actbio.2019.09.013
  50. Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform
    Achberger K, Probst C, Haderspeck J, Bolz S, Rogal J, Chuchuy J, Nikolova M, Cora V, Antkowiak L, Haq W, Shen N, Schenke-Layland K, Ueffing M, Liebau S, Loskill P.
    Elife. 2019 Aug 27;8:e46188.
    https://doi.org/10.7554/eLife.46188
  51. A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction
    Dolan EB, Hofmann B, de Vaal MH, Bellavia G, Straino S, Kovarova L, Pravda M, Velebny V, Daro D, Braun N, Monahan DS, Levey RE, O'Neill H, Hinderer S, Greensmith R, Monaghan MG, Schenke-Layland K, Dockery P, Murphy BP, Kelly HM, Wildhirt S, Duffy GP.
    Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109751.
    https://doi.org/10.1016/j.msec.2019.109751
  52. Imaging fibrosis in inflammatory diseases: targeting the exposed extracellular matrix
    Beziere N, Fuchs K, Maurer A, Reischl G, Brück J, Ghoreschi K, Fehrenbacher B, Berrio DC, Schenke-Layland K, Kohlhofer U, Quintanilla-Martinez L, Gawaz M, Kneilling M, Pichler B.
    Theranostics. 2019 Apr 13;9(10):2868-2881.
    https://doi.org/10.7150/thno.28892
  53. Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model
    Zbinden A, Marzi J, Schlünder K, Probst C, Urbanczyk M, Black S, Brauchle EM, Layland SL, Kraushaar U, Duffy G, Schenke-Layland K, Loskill P.
    Matrix Biol. 2020 Jan;85-86:205-220.
    https://doi.org/10.1016/j.matbio.2019.06.008
  54. Cardiac fibrosis - A short review of causes and therapeutic strategies
    Hinderer S, Schenke-Layland K.
    Adv Drug Deliv Rev. 2019 Jun;146:77-82.
    https://doi.org/10.1016/j.addr.2019.05.011
  55. Why, When, Who, What, How, and Where for Trainees Writing Literature Review Articles
    Koons GL, Schenke-Layland K, Mikos AG.
    Ann Biomed Eng. 2019 Nov;47(11):2334-2340.
    https://doi.org/10.1007/s10439-019-02290-5
  56. Dose-Dependent Tissue-Level Characterization of a Medical Atmospheric Pressure Argon Plasma Jet
    Weiss M, Barz J, Ackermann M, Utz R, Ghoul A, Weltmann KD, Stope MB, Wallwiener D, Schenke-Layland K, Oehr C, Brucker S, Loskill P.
    ACS Appl Mater Interfaces. 2019 Jun 5;11(22):19841-19853.
    https://doi.org/10.1021/acsami.9b04803
  57. Non-invasive detection of DNA methylation states in carcinoma and pluripotent stem cells using Raman microspectroscopy and imaging
    Daum R, Brauchle EM, Berrio DAC, Jurkowski TP, Schenke-Layland K.
    Sci Rep. 2019 May 7;9(1):7014.
    https://doi.org/10.1038/s41598-019-43520-z
  58. Non-invasive functional molecular phenotyping of human smooth muscle cells utilized in cardiovascular tissue engineering
    Marzi J, Brauchle EM, Schenke-Layland K, Rolle MW.
    Acta Biomater. 2019 Apr 15;89:193-205.
    https://doi.org/10.1016/j.actbio.2019.03.026
  59. Controlled and tuneable drug release from electrospun fibers and a non-invasive approach for cytotoxicity testing
    Piccirillo G, Carvajal Berrio DA, Laurita A, Pepe A, Bochicchio B, Schenke-Layland K, Hinderer S.
    Sci Rep. 2019 Mar 5;9(1):3446.
    https://doi.org/10.1038/s41598-019-40079-7
  60. Marker-Independent In Situ Quantitative Assessment of Residual Cryoprotectants in Cardiac Tissues
    Marzi J, Biermann AC, Brauchle EM, Brockbank KGM, Stock UA, Schenke-Layland K.
    Anal Chem. 2019 Feb 5;91(3):2266-2272.
    https://doi.org/10.1021/acs.analchem.8b04861
  61. Comparative Study of MSCA-1 and CD146 Isolated Periosteal Cell Subpopulations
    Umrath F, Thomalla C, Pöschel S, Schenke-Layland K, Reinert S, Alexander D.
    Cell Physiol Biochem. 2018;51(3):1193-1206.
    https://doi.org/10.1159/000495497
  62. Non-invasive characterization of hybrid gelatin:poly-l-lactide electrospun scaffolds using second harmonic generation and multiphoton imaging
    Piccirillo G , Ditaranto MV , Feuerer NFS , Carvajal Berrio DA , Brauchle EM , Pepe A , Bochicchio B , Schenke-Layland K , Hinderer S .
    J Mater Chem B. 2018 Oct 28;6(40):6399-6412.
    https://doi.org/10.1039/c8tb02026d
  63. Stem-cell based organ-on-a-chip models for diabetes research
    Rogal J, Zbinden A, Schenke-Layland K, Loskill P.
    Adv Drug Deliv Rev. 2019 Feb 1;140:101-128.
    https://doi.org/10.1016/j.addr.2018.10.010
  64. Improved long-term durability of allogeneic heart valves in the orthotopic sheep model
    Biermann AC, Marzi J, Brauchle E, Wichmann JL, Arendt CT, Puntmann V, Nagel E, Abdelaziz S, Winter AG, Brockbank KGM, Layland S, Schenke-Layland K, Stock UA.
    Eur J Cardiothorac Surg. 2019 Mar 1;55(3):484-493.
    https://doi.org/10.1093/ejcts/ezy292
  65. Influence of aflibercept on platelet activation profile
    Sobolewska B, Golenko J, Poeschel S, Grimmel C, Gatsiou A, Sopova K, Biedermann T, Schenke-Layland K, Stellos K, Ziemssen F.
    Exp Eye Res. 2018 Oct;175:166-172.
    https://doi.org/10.1016/j.exer.2018.06.009
  66. Biomechanical and biomolecular characterization of extracellular matrix structures in human colon carcinomas
    Brauchle E, Kasper J, Daum R, Schierbaum N, Falch C, Kirschniak A, Schäffer TE, Schenke-Layland K.
    Matrix Biol. 2018 Aug;68-69:180-193.
    https://doi.org/10.1016/j.matbio.2018.03.016
  67. Electroconductive Biohybrid Collagen/Pristine Graphene Composite Biomaterials with Enhanced Biological Activity
    Ryan AJ, Kearney CJ, Shen N, Khan U, Kelly AG, Probst C, Brauchle E, Biccai S, Garciarena CD, Vega-Mayoral V, Loskill P, Kerrigan SW, Kelly DJ, Schenke-Layland K, Coleman JN, O'Brien FJ.
    Adv Mater. 2018 Apr;30(15):e1706442.
    https://doi.org/10.1002/adma.201706442
  68. Surface functionalization of electrospun scaffolds using recombinant human decorin attracts circulating endothelial progenitor cells
    Hinderer S, Sudrow K, Schneider M, Holeiter M, Layland SL, Seifert M, Schenke-Layland K.
    Sci Rep. 2018 Jan 8;8(1):110.
    https://doi.org/10.1038/s41598-017-18382-y
  69. Impact of T-cell-mediated immune response on xenogeneic heart valve transplantation: short-term success and mid-term failure
    Biermann AC, Marzi J, Brauchle E, Schneider M, Kornberger A, Abdelaziz S, Wichmann JL, Arendt CT, Nagel E, Brockbank KGM, Seifert M, Schenke-Layland K, Stock UA.
    Eur J Cardiothorac Surg. 2018 Apr 1;53(4):784-792.
    https://doi.org/10.1093/ejcts/ezx396
  70. A flow bioreactor system compatible with real-time two-photon fluorescence lifetime imaging microscopy
    Shen N, Riedl JA, Carvajal Berrio DA, Davis Z, Monaghan MG, Layland SL, Hinderer S, Schenke-Layland K.
    Biomed Mater. 2018 Feb 2;13(2):024101.
    https://doi.org/10.1088/1748-605X/aa9b3c
  71. Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease
    Fitzgerald JC, Zimprich A, Carvajal Berrio DA, Schindler KM, Maurer B, Schulte C, Bus C, Hauser AK, Kübler M, Lewin R, Bobbili DR, Schwarz LM, Vartholomaiou E, Brockmann K, Wüst R, Madlung J, Nordheim A, Riess O, Martins LM, Glaab E, May P, Schenke-Layland K, Picard D, Sharma M, Gasser T, Krüger R.
    Brain. 2017 Sep 1;140(9):2444-2459.
    https://doi.org/10.1093/brain/awx202
  72. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection
    Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG.
    Cell Rep. 2017 Oct 10;21(2):517-532.
    https://doi.org/10.1016/j.celrep.2017.09.047
  73. Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals
    Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, Pöschel S, Layland SL, Holeiter M, Knolle S, Brauchle E, Nsair A, Hinderer S, Schenke-Layland K.
    Stem Cell Reports. 2017 Jul 11;9(1):122-135.
    https://doi.org/10.1016/j.stemcr.2017.04.021
  74. Exogenous miR-29B Delivery Through a Hyaluronan-Based Injectable System Yields Functional Maintenance of the Infarcted Myocardium
    Monaghan MG, Holeiter M, Brauchle E, Layland SL, Lu Y, Deb A, Pandit A, Nsair A, Schenke-Layland K.
    Tissue Eng Part A. 2018 Jan;24(1-2):57-67.
    https://doi.org/10.1089/ten.TEA.2016.0527
  75. Special Issue "Extracellular Matrix Proteins and Mimics"
    Schenke-Layland K.
    Acta Biomater. 2017 Apr 1;52:iv.
    https://doi.org/10.1016/j.actbio.2017.03.029
  76. Raman Spectroscopic Analyses of Jaw Periosteal Cell Mineralization
    Brauchle E, Carvajal Berrio D, Rieger M, Schenke-Layland K, Reinert S, Alexander D.
    Stem Cells Int. 2017;2017:1651376.
    https://doi.org/10.1155/2017/1651376
  77. Applying phasor approach analysis of multiphoton FLIM measurements to probe the metabolic activity of three-dimensional in vitro cell culture models
    Lakner PH, Monaghan MG, Möller Y, Olayioye MA, Schenke-Layland K.
    Sci Rep. 2017 Feb 13;7:42730.
    https://doi.org/10.1038/srep42730
  78. In Vivo Human Somitogenesis Guides Somite Development from hPSCs
    Xi H, Fujiwara W, Gonzalez K, Jan M, Liebscher S, Van Handel B, Schenke-Layland K, Pyle AD.
    Cell Rep. 2017 Feb 7;18(6):1573-1585.
    https://doi.org/10.1016/j.celrep.2017.01.040
  79. Enhanced elastin synthesis and maturation in human vascular smooth muscle tissue derived from induced-pluripotent stem cells
    Eoh JH, Shen N, Burke JA, Hinderer S, Xia Z, Schenke-Layland K, Gerecht S.
    Acta Biomater. 2017 Apr 1;52:49-59.
    https://doi.org/10.1016/j.actbio.2017.01.083
  80. Allograft Heart Valves: Current Aspects and Future Applications
    Lisy M, Kalender G, Schenke-Layland K, Brockbank KG, Biermann A, Stock UA.
    Biopreserv Biobank. 2017 Apr;15(2):148-157.
    https://doi.org/10.1089/bio.2016.0070
  81. Raman microspectroscopy as a diagnostic tool for the non-invasive analysis of fibrillin-1 deficiency in the skin and in the in vitro skin models
    Brauchle E, Bauer H, Fernes P, Zuk A, Schenke-Layland K, Sengle G.
    Acta Biomater. 2017 Apr 1;52:41-48.
    https://doi.org/10.1016/j.actbio.2016.12.019
  82. Electrospun poly-l-lactide scaffold for the controlled and targeted delivery of a synthetically obtained Diclofenac prodrug to treat actinic keratosis
    Piccirillo G, Bochicchio B, Pepe A, Schenke-Layland K, Hinderer S.
    Acta Biomater. 2017 Apr 1;52:187-196.
    https://doi.org/10.1016/j.actbio.2016.11.002
  83. Differentiation of human embryonic stem cells to HOXA(+) hemogenic vasculature that resembles the aorta-gonad-mesonephros
    Ng ES, Azzola L, Bruveris FF, Calvanese V, Phipson B, Vlahos K, Hirst C, Jokubaitis VJ, Yu QC, Maksimovic J, Liebscher S, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock DN, Nilsson SK, Saffery R, Schenke-Layland K, Oshlack A, Mikkola HK, Stanley EG, Elefanty AG.
    Nat Biotechnol. 2016 Nov;34(11):1168-1179.
    https://doi.org/10.1038/nbt.3702
  84. Raman microspectroscopy for the development and screening of recombinant cell lines
    Brauchle E, Schenke-Layland K.
    Biotechnol J. 2017 Jan;12(1).
    https://doi.org/10.1002/biot.201600412
  85. Mononuclear phagocytes contribute to intestinal invasion and dissemination of Yersinia enterocolitica
    Drechsler-Hake D, Alamir H, Hahn J, Günter M, Wagner S, Schütz M, Bohn E, Schenke-Layland K, Pisano F, Dersch P, Autenrieth IB, Autenrieth SE.
    Int J Med Microbiol. 2016 Sep;306(6):357-66.
    https://doi.org/10.1016/j.ijmm.2016.04.002
  86. Enabling Multiphoton and Second Harmonic Generation Imaging in Paraffin-Embedded and Histologically Stained Sections
    Monaghan MG, Kroll S, Brucker SY, Schenke-Layland K.
    Tissue Eng Part C Methods. 2016 Jun;22(6):517-23.
    https://doi.org/10.1089/ten.TEC.2016.0071
  87. Cardiomyocyte generation from somatic sources - current status and future directions
    Monaghan MG, Holeiter M, Layland SL, Schenke-Layland K.
    Curr Opin Biotechnol. 2016 Aug;40:49-55.
    https://doi.org/10.1016/j.copbio.2016.02.014
  88. Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology
    Felka T, Rothdiener M, Bast S, Uynuk-Ool T, Zouhair S, Ochs BG, De Zwart P, Stoeckle U, Aicher WK, Hart ML, Shiozawa T, Grodzinsky AJ, Schenke-Layland K, Venkatesan JK, Cucchiarini M, Madry H, Kurz B, Rolauffs B.
    Osteoarthritis Cartilage. 2016 Jul;24(7):1200-9.
    https://doi.org/10.1016/j.joca.2016.02.001
  89. Visualizing tropoelastin in a long-term human elastic fibre cell culture model
    Halm M, Schenke-Layland K, Jaspers S, Wenck H, Fischer F.
    Sci Rep. 2016 Feb 4;6:20378.
    https://doi.org/10.1038/srep20378
  90. Non-invasive Chamber-Specific Identification of Cardiomyocytes in Differentiating Pluripotent Stem Cells
    Brauchle E, Knopf A, Bauer H, Shen N, Linder S, Monaghan MG, Ellwanger K, Layland SL, Brucker SY, Nsair A, Schenke-Layland K.
    Stem Cell Reports. 2016 Feb 9;6(2):188-99.
    https://doi.org/10.1016/j.stemcr.2015.12.007
  91. PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming
    Armbruster NS, Richardson JR, Schreiner J, Klenk J, Günter M, Kretschmer D, Pöschel S, Schenke-Layland K, Kalbacher H, Clark K, Autenrieth SE.
    J Immunol. 2016 Feb 1;196(3):1284-92.
    https://doi.org/10.4049/jimmunol.1502232
  92. Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development
    Monaghan MG, Linneweh M, Liebscher S, Van Handel B, Layland SL, Schenke-Layland K.
    Development. 2016 Feb 1;143(3):473-82.
    https://doi.org/10.1242/dev.133843
  93. ECM and ECM-like materials - Biomaterials for applications in regenerative medicine and cancer therapy
    Hinderer S, Layland SL, Schenke-Layland K.
    Adv Drug Deliv Rev. 2016 Feb 1;97:260-9.
    https://doi.org/10.1016/j.addr.2015.11.019
  94. Modulation of inflammation and angiogenesis and changes in ECM GAG-activity via dual delivery of nucleic acids
    Browne S, Monaghan MG, Brauchle E, Berrio DC, Chantepie S, Papy-Garcia D, Schenke-Layland K, Pandit A.
    Biomaterials. 2015 Nov;69:133-47.
    https://doi.org/10.1016/j.biomaterials.2015.08.012
  95. Prospects for regenerative medicine approaches in women's health
    Schenke-Layland K, Brucker SY.
    J Anat. 2015 Dec;227(6):781-5.
    https://doi.org/10.1111/joa.12336
  96. Optical reprogramming and optical characterization of cells using femtosecond lasers
    Uchugonova A, Breunig HG, Augspurger C, Monaghan M, Schenke-Layland K, König K.
    In: König K, Ostendorf A, editors. Optically Induced Nanostructures: Biomedical and Technical Applications. Berlin: De Gruyter; 2015 Jun 23. Chapter 1.
    https://doi.org/None
  97. Fluorescent Ly6G antibodies determine macrophage phagocytosis of neutrophils and alter the retrieval of neutrophils in mice
    Bucher K, Schmitt F, Autenrieth SE, Dillmann I, Nürnberg B, Schenke-Layland K, Beer-Hammer S.
    J Leukoc Biol. 2015 Sep;98(3):365-72.
    https://doi.org/10.1189/jlb.1AB1014-488RR
  98. In vitro elastogenesis: instructing human vascular smooth muscle cells to generate an elastic fiber-containing extracellular matrix scaffold
    Hinderer S, Shena N, Ringuette LJ, Hansmann J, Reinhardt DP, Brucker SY, Davis EC, Schenke-Layland K.
    Biomed Mater. 2015 Mar 18;10(3):034102.
    https://doi.org/10.1088/1748-6041/10/3/034102
  99. Generation and Assessment of Functional Biomaterial Scaffolds for Applications in Cardiovascular Tissue Engineering and Regenerative Medicine
    Hinderer S, Brauchle E, Schenke-Layland K.
    Adv Healthc Mater. 2015 Nov 18;4(16):2326-41.
    https://doi.org/10.1002/adhm.201400762
  100. Human eye development is characterized by coordinated expression of fibrillin isoforms
    Hubmacher D, Reinhardt DP, Plesec T, Schenke-Layland K, Apte SS.
    Invest Ophthalmol Vis Sci. 2014 Nov 18;55(12):7934-44.
    https://doi.org/10.1167/iovs.14-15453
  101. Drug and cell delivery for cardiac regeneration
    Hastings CL, Roche ET, Ruiz-Hernandez E, Schenke-Layland K, Walsh CJ, Duffy GP.
    Adv Drug Deliv Rev. 2015 Apr;84:85-106.
    https://doi.org/10.1016/j.addr.2014.08.006
  102. Raman spectroscopy as an analytical tool for melanoma research
    Brauchle E, Noor S, Holtorf E, Garbe C, Schenke-Layland K, Busch C.
    Clin Exp Dermatol. 2014 Jul;39(5):636-45.
    https://doi.org/10.1111/ced.12357
  103. Preserved bioactivity and tunable release of a SDF1-GPVI bi-specific protein using photo-crosslinked PEGda hydrogels
    Schesny MK, Monaghan M, Bindermann AH, Freund D, Seifert M, Eble JA, Vogel S, Gawaz MP, Hinderer S, Schenke-Layland K.
    Biomaterials. 2014 Aug;35(25):7180-7.
    https://doi.org/10.1016/j.biomaterials.2014.04.116
  104. Cell death stages in single apoptotic and necrotic cells monitored by Raman microspectroscopy
    Brauchle E, Thude S, Brucker SY, Schenke-Layland K.
    Sci Rep. 2014 Apr 15;4:4698.
    https://doi.org/10.1038/srep04698
  105. A collagen-based scaffold delivering exogenous microrna-29B to modulate extracellular matrix remodeling
    Monaghan M, Browne S, Schenke-Layland K, Pandit A.
    Mol Ther. 2014 Apr;22(4):786-96.
    https://doi.org/10.1038/mt.2013.288
  106. Engineering of a bio-functionalized hybrid off-the-shelf heart valve
    Hinderer S, Seifert J, Votteler M, Shen N, Rheinlaender J, Schäffer TE, Schenke-Layland K.
    Biomaterials. 2014 Feb;35(7):2130-9.
    https://doi.org/10.1016/j.biomaterials.2013.10.080
  107. A human in vitro model that mimics the renal proximal tubule
    Hoppensack A, Kazanecki CC, Colter D, Gosiewska A, Schanz J, Walles H, Schenke-Layland K.
    Tissue Eng Part C Methods. 2014 Jul;20(7):599-609.
    https://doi.org/10.1089/ten.TEC.2013.0446
  108. Design and analysis of a squamous cell carcinoma in vitro model system
    Brauchle E, Johannsen H, Nolan S, Thude S, Schenke-Layland K.
    Biomaterials. 2013 Oct;34(30):7401-7.
    https://doi.org/10.1016/j.biomaterials.2013.06.016
  109. Elastogenesis at the onset of human cardiac valve development
    Votteler M, Berrio DA, Horke A, Sabatier L, Reinhardt DP, Nsair A, Aikawa E, Schenke-Layland K.
    Development. 2013 Jun;140(11):2345-53.
    https://doi.org/10.1242/dev.093500
  110. Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha
    Sdek P, Oyama K, Angelis E, Chan SS, Schenke-Layland K, MacLellan WR.
    PLoS One. 2013;8(3):e58319.
    https://doi.org/10.1371/journal.pone.0058319
  111. Strategies in tissue engineering and regenerative medicine
    Schenke-Layland K, Walles H.
    Biotechnol J. 2013 Mar;8(3):278-9.
    https://doi.org/10.1002/biot.201300043
  112. Tracheal tissue engineering: building on a strong foundation
    Hinderer S, Schenke-Layland K.
    Expert Rev Med Devices. 2013 Jan;10(1):33-5.
    https://doi.org/10.1586/erd.12.74
  113. Raman spectroscopy in biomedicine - non-invasive in vitro analysis of cells and extracellular matrix components in tissues
    Brauchle E, Schenke-Layland K.
    Biotechnol J. 2013 Mar;8(3):288-97.
    https://doi.org/10.1002/biot.201200163
  114. RNA isolation from fetal and adult human tissues for transcriptional profiling
    Votteler M, Layland SL, Lill G, Brockbank KG, Horke A, Schenke-Layland K.
    Biotechnol J. 2013 Mar;8(3):338-44.
    https://doi.org/10.1002/biot.201200164
  115. Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells
    Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR.
    PLoS One. 2012;7(10):e45603.
    https://doi.org/10.1371/journal.pone.0045603
  116. Non-contact, label-free monitoring of cells and extracellular matrix using Raman spectroscopy
    Votteler M, Carvajal Berrio DA, Pudlas M, Walles H, Schenke-Layland K.
    J Vis Exp. 2012 May 29;(63):3977.
    https://doi.org/10.3791/3977
  117. Non-invasive identification of proteoglycans and chondrocyte differentiation state by Raman microspectroscopy
    Pudlas M, Brauchle E, Klein TJ, Hutmacher DW, Schenke-Layland K.
    J Biophotonics. 2013 Feb;6(2):205-11.
    https://doi.org/10.1002/jbio.201200064
  118. Words of wisdom: Re: Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
    Vaegler M, Schenke-Layland K, Stenzl A.
    Eur Urol. 2012 Jun;61(6):1263-4.
    https://doi.org/10.1016/j.eururo.2012.03.025
  119. Engineering of fibrillar decorin matrices for a tissue-engineered trachea
    Hinderer S, Schesny M, Bayrak A, Ibold B, Hampel M, Walles T, Stock UA, Seifert M, Schenke-Layland K.
    Biomaterials. 2012 Jul;33(21):5259-66.
    https://doi.org/10.1016/j.biomaterials.2012.03.075
  120. Oligonucleotide and Parylene Surface Coating of Polystyrene and ePTFE for Improved Endothelial Cell Attachment and Hemocompatibility
    Schleicher M, Hansmann J, Elkin B, Kluger PJ, Liebscher S, Huber AJ, Fritze O, Schille C, Müller M, Schenke-Layland K, Seifert M, Walles H, Wendel HP, Stock UA.
    Int J Biomater. 2012;2012:397813.
    https://doi.org/10.1155/2012/397813
  121. Preclinical evaluation of ice-free cryopreserved arteries: structural integrity and hemocompatibility
    Huber AJ, Brockbank KG, Riemann I, Schleicher M, Schenke-Layland K, Fritze O, Wendel HP, Stock UA.
    Cells Tissues Organs. 2012;196(3):262-70.
    https://doi.org/10.1159/000334544
  122. Ice-free cryopreservation of heart valve allografts: better extracellular matrix preservation in vivo and preclinical results
    Brockbank KG, Schenke-Layland K, Greene ED, Chen Z, Fritze O, Schleicher M, Kaulitz R, Riemann I, Fend F, Albes JM, Stock UA, Lisy M.
    Cell Tissue Bank. 2012 Dec;13(4):663-71.
    https://doi.org/10.1007/s10561-011-9288-7
  123. Age-related changes in the elastic tissue of the human aorta
    Fritze O, Romero B, Schleicher M, Jacob MP, Oh DY, Starcher B, Schenke-Layland K, Bujan J, Stock UA.
    J Vasc Res. 2012;49(1):77-86.
    https://doi.org/10.1159/000331278
  124. Skin tissue engineering--in vivo and in vitro applications
    Groeber F, Holeiter M, Hampel M, Hinderer S, Schenke-Layland K.
    Clin Plast Surg. 2012 Jan;39(1):33-58.
    https://doi.org/10.1016/j.cps.2011.09.007
  125. Raman spectroscopy for the non-contact and non-destructive monitoring of collagen damage within tissues
    Votteler M, Carvajal Berrio DA, Pudlas M, Walles H, Stock UA, Schenke-Layland K.
    J Biophotonics. 2012 Jan;5(1):47-56.
    https://doi.org/10.1002/jbio.201100068
  126. Raman spectroscopy: a noninvasive analysis tool for the discrimination of human skin cells
    Pudlas M, Koch S, Bolwien C, Thude S, Jenne N, Hirth T, Walles H, Schenke-Layland K.
    Tissue Eng Part C Methods. 2011 Oct;17(10):1027-40.
    https://doi.org/10.1089/ten.tec.2011.0082
  127. The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine
    Pusch J, Votteler M, Göhler S, Engl J, Hampel M, Walles H, Schenke-Layland K.
    Biomaterials. 2011 Oct;32(30):7469-78.
    https://doi.org/10.1016/j.biomaterials.2011.06.035
  128. In vitro human tissue models--moving towards personalized regenerative medicine
    Schenke-Layland K, Nerem RM.
    Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):195-6.
    https://doi.org/10.1016/j.addr.2011.05.001
  129. Allogeneic heart valve storage above the glass transition at -80°C
    Brockbank KG, Wright GJ, Yao H, Greene ED, Chen ZZ, Schenke-Layland K.
    Ann Thorac Surg. 2011 Jun;91(6):1829-35.
    https://doi.org/10.1016/j.athoracsur.2011.02.043
  130. From tissue engineering to regenerative medicine--the potential and the pitfalls
    Schenke-Layland K.
    Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):193-4.
    https://doi.org/10.1016/j.addr.2011.04.003
  131. Recapitulation of the embryonic cardiovascular progenitor cell niche
    Schenke-Layland K, Nsair A, Van Handel B, Angelis E, Gluck JM, Votteler M, Goldhaber JI, Mikkola HK, Kahn M, Maclellan WR.
    Biomaterials. 2011 Apr;32(11):2748-56.
    https://doi.org/10.1016/j.biomaterials.2010.12.046
  132. Skin tissue engineering--in vivo and in vitro applications
    Groeber F, Holeiter M, Hampel M, Hinderer S, Schenke-Layland K.
    Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):352-66.
    https://doi.org/10.1016/j.addr.2011.01.005
  133. Guidance for removal of fetal bovine serum from cryopreserved heart valve processing
    Brockbank KG, Heacox AE, Schenke-Layland K.
    Cells Tissues Organs. 2011;193(4):264-73.
    https://doi.org/10.1159/000321166
  134. Stem cell microenvironments--unveiling the secret of how stem cell fate is defined
    Votteler M, Kluger PJ, Walles H, Schenke-Layland K.
    Macromol Biosci. 2010 Nov 10;10(11):1302-15.
    https://doi.org/10.1002/mabi.201000102
  135. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells
    Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM.
    Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13742-7.
    https://doi.org/10.1073/pnas.1002077107
  136. Electrospun poly(D/L-lactide-co-L-lactide) hybrid matrix: a novel scaffold material for soft tissue engineering
    Kluger PJ, Wyrwa R, Weisser J, Maierle J, Votteler M, Rode C, Schnabelrauch M, Walles H, Schenke-Layland K.
    J Mater Sci Mater Med. 2010 Sep;21(9):2665-71.
    https://doi.org/10.1007/s10856-010-4128-z
  137. Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse
    Li X, Wu K, Edman M, Schenke-Layland K, MacVeigh-Aloni M, Janga SR, Schulz B, Hamm-Alvarez SF.
    Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5019-29.
    https://doi.org/10.1167/iovs.09-4523
  138. The performance of ice-free cryopreserved heart valve allografts in an orthotopic pulmonary sheep model
    Lisy M, Pennecke J, Brockbank KG, Fritze O, Schleicher M, Schenke-Layland K, Kaulitz R, Riemann I, Weber CN, Braun J, Mueller KE, Fend F, Scheunert T, Gruber AD, Albes JM, Huber AJ, Stock UA.
    Biomaterials. 2010 Jul;31(20):5306-11.
    https://doi.org/10.1016/j.biomaterials.2010.03.038
  139. Simplified pulse reactor for real-time long-term in vitro testing of biological heart valves
    Schleicher M, Sammler G, Schmauder M, Fritze O, Huber AJ, Schenke-Layland K, Ditze G, Stock UA.
    Ann Biomed Eng. 2010 May;38(5):1919-27.
    https://doi.org/10.1007/s10439-010-9975-8
  140. Impact of heart valve decellularization on 3-D ultrastructure, immunogenicity and thrombogenicity
    Zhou J, Fritze O, Schleicher M, Wendel HP, Schenke-Layland K, Harasztosi C, Hu S, Stock UA.
    Biomaterials. 2010 Mar;31(9):2549-54.
    https://doi.org/10.1016/j.biomaterials.2009.11.088
  141. Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy
    Schenke-Layland K, Xie J, Magnusson M, Angelis E, Li X, Wu K, Reinhardt DP, Maclellan WR, Hamm-Alvarez SF.
    Exp Eye Res. 2010 Feb;90(2):223-37.
    https://doi.org/10.1016/j.exer.2009.10.008
  142. Facilitated noninvasive visualization of collagen and elastin in blood vessels
    Fritze O, Schleicher M, König K, Schenke-Layland K, Stock U, Harasztosi C.
    Tissue Eng Part C Methods. 2010 Aug;16(4):705-10.
    https://doi.org/10.1089/ten.TEC.2009.0309
  143. Induced pluripotent stem cells: it's like déjà vu all over again
    Schenke-Layland K, MacLellan WR.
    Circulation. 2009 Oct 13;120(15):1462-4.
    https://doi.org/10.1161/CIRCULATIONAHA.109.898544
  144. Invited commentary
    Nsair A, Schenke-Layland K.
    Ann Thorac Surg. 2009 Aug;88(2):513-4.
    https://doi.org/10.1016/j.athoracsur.2009.04.094
  145. Cardiomyopathy is associated with structural remodelling of heart valve extracellular matrix
    Schenke-Layland K, Stock UA, Nsair A, Xie J, Angelis E, Fonseca CG, Larbig R, Mahajan A, Shivkumar K, Fishbein MC, MacLellan WR.
    Eur Heart J. 2009 Sep;30(18):2254-65.
    https://doi.org/10.1093/eurheartj/ehp267
  146. The use of three-dimensional nanostructures to instruct cells to produce extracellular matrix for regenerative medicine strategies
    Schenke-Layland K, Rofail F, Heydarkhan S, Gluck JM, Ingle NP, Angelis E, Choi CH, MacLellan WR, Beygui RE, Shemin RJ, Heydarkhan-Hagvall S.
    Biomaterials. 2009 Sep;30(27):4665-75.
    https://doi.org/10.1016/j.biomaterials.2009.05.033
  147. Non-invasive multiphoton imaging of extracellular matrix structures
    Schenke-Layland K.
    J Biophotonics. 2008 Dec;1(6):451-62.
    https://doi.org/10.1002/jbio.200810045
  148. Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly
    Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wang XC, Maclellan WR, Crooks GM.
    Stem Cells Dev. 2009 Jul-Aug;18(6):919-28.
    https://doi.org/10.1089/scd.2008.0293
  149. Adipose tissue-derived cells improve cardiac function following myocardial infarction
    Schenke-Layland K, Strem BM, Jordan MC, Deemedio MT, Hedrick MH, Roos KP, Fraser JK, Maclellan WR.
    J Surg Res. 2009 May 15;153(2):217-23.
    https://doi.org/10.1016/j.jss.2008.03.019
  150. Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages
    Schenke-Layland K, Rhodes KE, Angelis E, Butylkova Y, Heydarkhan-Hagvall S, Gekas C, Zhang R, Goldhaber JI, Mikkola HK, Plath K, MacLellan WR.
    Stem Cells. 2008 Jun;26(6):1537-46.
    https://doi.org/10.1634/stemcells.2008-0033
  151. Quantitative second harmonic generation imaging of cartilage damage
    Brockbank KG, MacLellan WR, Xie J, Hamm-Alvarez SF, Chen ZZ, Schenke-Layland K.
    Cell Tissue Bank. 2008 Dec;9(4):299-307.
    https://doi.org/10.1007/s10561-008-9070-7
  152. A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium
    Angelis E, Garcia A, Chan SS, Schenke-Layland K, Ren S, Goodfellow SJ, Jordan MC, Roos KP, White RJ, MacLellan WR.
    Circ Res. 2008 May 23;102(10):1222-9.
    https://doi.org/10.1161/CIRCRESAHA.107.163550
  153. Three-dimensional electrospun ECM-based hybrid scaffolds for cardiovascular tissue engineering
    Heydarkhan-Hagvall S, Schenke-Layland K, Dhanasopon AP, Rofail F, Smith H, Wu BM, Shemin R, Beygui RE, MacLellan WR.
    Biomaterials. 2008 Jul;29(19):2907-14.
    https://doi.org/10.1016/j.biomaterials.2008.03.034
  154. Human adipose stem cells: a potential cell source for cardiovascular tissue engineering
    Heydarkhan-Hagvall S, Schenke-Layland K, Yang JQ, Heydarkhan S, Xu Y, Zuk PA, MacLellan WR, Beygui RE.
    Cells Tissues Organs. 2008;187(4):263-74.
    https://doi.org/10.1159/000113407
  155. Influence of systematically varied nano-scale topography on cell morphology and adhesion
    Heydarkhan-Hagvall S, Choi CH, Dunn J, Heydarkhan S, Schenke-Layland K, MacLellan WR, Beygui RE.
    Cell Commun Adhes. 2007 Sep-Oct;14(5):181-94.
    https://doi.org/10.1080/15419060701755594
  156. The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury
    Anderson CD, Heydarkhan-Hagvall S, Schenke-Layland K, Yang JQ, Jordan MC, Kim JK, Brown DA, Zuk PA, Laks H, Roos KP, Maclellan WR, Beygui RE.
    J Surg Res. 2008 Aug;148(2):164-71.
    https://doi.org/10.1016/j.jss.2007.08.005
  157. Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome
    Schenke-Layland K, Xie J, Angelis E, Starcher B, Wu K, Riemann I, MacLellan WR, Hamm-Alvarez SF.
    Matrix Biol. 2008 Jan;27(1):53-66.
    https://doi.org/10.1016/j.matbio.2007.07.005
  158. Phenotypical plasticity of vascular smooth muscle cells-effect of in vitro and in vivo shear stress for tissue engineering of blood vessels
    Opitz F, Schenke-Layland K, Cohnert TU, Stock UA.
    Tissue Eng. 2007 Oct;13(10):2505-14.
    https://doi.org/10.1089/ten.2006.0424
  159. Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability
    Schenke-Layland K, Xie J, Heydarkhan-Hagvall S, Hamm-Alvarez SF, Stock UA, Brockbank KG, MacLellan WR.
    Ann Thorac Surg. 2007 May;83(5):1641-50.
    https://doi.org/10.1016/j.athoracsur.2006.12.005
  160. Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells
    Schenke-Layland K, Angelis E, Rhodes KE, Heydarkhan-Hagvall S, Mikkola HK, Maclellan WR.
    Stem Cells. 2007 Jun;25(6):1529-38.
    https://doi.org/10.1634/stemcells.2006-0729
  161. Two-photon microscopes and in vivo multiphoton tomographs--powerful diagnostic tools for tissue engineering and drug delivery
    Schenke-Layland K, Riemann I, Damour O, Stock UA, König K.
    Adv Drug Deliv Rev. 2006 Sep 15;58(7):878-96.
    https://doi.org/10.1016/j.addr.2006.07.004
  162. Prevention of device-related tissue damage during percutaneous deployment of tissue-engineered heart valves
    Stock UA, Degenkolbe I, Attmann T, Schenke-Layland K, Freitag S, Lutter G.
    J Thorac Cardiovasc Surg. 2006 Jun;131(6):1323-30.
    https://doi.org/10.1016/j.jtcvs.2006.01.053
  163. Impact of cryopreservation on extracellular matrix structures of heart valve leaflets
    Schenke-Layland K, Madershahian N, Riemann I, Starcher B, Halbhuber KJ, König K, Stock UA.
    Ann Thorac Surg. 2006 Mar;81(3):918-26.
    https://doi.org/10.1016/j.athoracsur.2005.09.016
  164. Performance of decellularized xenogeneic tissue in heart valve replacement
    Stock UA, Schenke-Layland K.
    Biomaterials. 2006 Jan;27(1):1-2.
    https://doi.org/10.1016/j.biomaterials.2005.05.100
  165. Imaging of cardiovascular structures using near-infrared femtosecond multiphoton laser scanning microscopy
    Schenke-Layland K, Riemann I, Stock UA, König K.
    J Biomed Opt. 2005 Mar-Apr;10(2):024017.
    https://doi.org/10.1117/1.1896966
  166. Tissue engineering of aortic tissue: dire consequence of suboptimal elastic fiber synthesis in vivo
    Opitz F, Schenke-Layland K, Cohnert TU, Starcher B, Halbhuber KJ, Martin DP, Stock UA.
    Cardiovasc Res. 2004 Sep 1;63(4):719-30.
    https://doi.org/10.1016/j.cardiores.2004.05.002
  167. Multiphoton autofluorescence imaging of intratissue elastic fibers
    König K, Schenke-Layland K, Riemann I, Stock UA.
    Biomaterials. 2005 Feb;26(5):495-500.
    https://doi.org/10.1016/j.biomaterials.2004.02.059
  168. Comparative study of cellular and extracellular matrix composition of native and tissue engineered heart valves
    Schenke-Layland K, Riemann I, Opitz F, König K, Halbhuber KJ, Stock UA.
    Matrix Biol. 2004 May;23(2):113-25.
    https://doi.org/10.1016/j.matbio.2004.03.005
  169. ProteinChip system technology: a powerful tool to analyze expression differences in tissue-engineered blood vessels
    Opitz F, Melle C, Schenke-Layland K, Degenkolbe I, Martin DP, Von Eggeling F, Wahlers T, Stock UA.
    Tissue Eng. 2004 Mar-Apr;10(3-4):611-20.
    https://doi.org/10.1089/107632704323061960
  170. Tissue engineering of ovine aortic blood vessel substitutes using applied shear stress and enzymatically derived vascular smooth muscle cells
    Opitz F, Schenke-Layland K, Richter W, Martin DP, Degenkolbe I, Wahlers T, Stock UA.
    Ann Biomed Eng. 2004 Feb;32(2):212-22.
    https://doi.org/10.1023/b:abme.0000012741.85600.f1
  171. Complete dynamic repopulation of decellularized heart valves by application of defined physical signals-an in vitro study
    Schenke-Layland K, Opitz F, Gross M, Döring C, Halbhuber KJ, Schirrmeister F, Wahlers T, Stock UA.
    Cardiovasc Res. 2003 Dec 1;60(3):497-509.
    https://doi.org/10.1016/j.cardiores.2003.09.002
  172. Impact of decellularization of xenogeneic tissue on extracellular matrix integrity for tissue engineering of heart valves
    Schenke-Layland K, Vasilevski O, Opitz F, König K, Riemann I, Halbhuber KJ, Wahlers T, Stock UA.
    J Struct Biol. 2003 Sep;143(3):201-8.
    https://doi.org/10.1016/j.jsb.2003.08.002
  173. cAMP-induced Interleukin-10 promoter activation depends on CCAAT/enhancer-binding protein expression and monocytic differentiation
    Brenner S, Prösch S, Schenke-Layland K, Riese U, Gausmann U, Platzer C.
    J Biol Chem. 2003 Feb 21;278(8):5597-604.
    https://doi.org/10.1074/jbc.M207448200